Physiological functions of mitochondrial Na+-Ca2+ exchanger, NCLX, in lymphocytes, 2019, Takeuchi et al

Andy · Dec 15, 2019

Highlights

• NCLX is involved in mitochondria-ER Ca2+ recycling in B lymphocytes.
• NCLX is important for Ca2+ response to B cell receptor stimulation, motility and chemotaxis of B lymphocytes.
• Contribution of NCLX is minor in T lymphocytes.

Abstract
Roles of mitochondrial Na+-Ca2+ exchanger, NCLX, were studied in B lymphocytes such as heterozygous NCLX knockout DT40 cells, NCLX knockdown A20 cells, and native mouse spleen B lymphocytes treated with a NCLX blocker, CGP-37157. Cytosolic Ca2+ response to B cell receptor stimulation was impaired in these B lymphocytes, demonstrating importance of mitochondria-ER Ca2+ recycling via NCLX and sarco/endoplasmic reticulum Ca2+-ATPase SERCA, and interaction with store-operated Ca2+ entry. NCLX was also associated with motility and chemotaxis of B lymphocyte. Contrary to B lymphocytes, contribution of NCLX in mouse spleen T lymphocytes was minor.
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Paywall, https://www.sciencedirect.com/science/article/pii/S0143416019301812
Scihub, https://sci-hub.se/10.1016/j.ceca.2019.102114

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Physiological functions of mitochondrial Na+-Ca2+ exchanger, NCLX, in lymphocytes, 2019, Takeuchi et al

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Physiological functions of mitochondrial Na+-Ca2+ exchanger, NCLX, in lymphocytes, 2019, Takeuchi et al

Andy Committee Member

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