Highlights • Many cases of COVID-19 land up in “post-COVID-19 Syndrome” which is a persistent condition of chronic fatigue, disturbed sleep/wake cycle, neuro-cognitive implications, and progressive anhedonia. • It is state of post-exertional neuroimmune exhaustion. • There is no specific medication or speedy treatment for post-viral fatigue or chronic fatigue syndrome. • The most effective current treatment is total rest. Abstract Long-COVID, also referred to as post-acute COVID-19, chronic COVID-19, post-COVID syndrome, or post-acute sequelae of SARS-CoV-2 infection (PASC), generally refers to symptoms that develop during or after acute COVID-19 illness, continue for ≥12 weeks, and are not explained by an alternative diagnosis. It is not yet known whether “long-COVID” represents a new syndrome unique to COVID-19 or overlaps with recovery from similar illnesses. It's difficult for physicians to predict when symptoms will improve as it varies differently in different people. Patient's recovery depends on various factors including age, associated comorbidities, severity of COVID-19 infection. Some symptoms, like fatigue, might continue even while others improve or go away. This review addresses the pathogenesis, presentation of post covid fatigue, its severity and its management. Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0019570721001177
