Review Post-dengue fatigue syndrome: A comprehensive review of an emerging clinical entity, 2024, Garg

https://karnatakamedj.com/post-deng...ensive-review-of-an-emerging-clinical-entity/

Review Article
ARTICLE IN PRESS
doi:
10.25259/KMJ_27_2024
Post-dengue fatigue syndrome: A comprehensive review of an emerging clinical entity
Rahul Garg1,
1Department of Medicine, F H Medical College, Agra, Uttar Pradesh, India.
*Corresponding author: Rahul Garg, Department of Medicine,F H Medical College, Agra, Uttar Pradesh, India. gargrahul27@gmail.com


Received: 2024-07-10, Accepted: 2024-08-11, Epub ahead of print: 2024-10-22,

How to cite this article: Garg R. Post-dengue fatigue syndrome: A comprehensive review of an emerging clinical entity. Karnataka Med J. doi: 10.25259/KMJ_27_2024


Abstract
Post-dengue fatigue syndrome (PDFS) is an emerging clinical entity characterised by persistent, debilitating fatigue and other symptoms following acute dengue infection.

This review synthesises current evidence on the epidemiology, clinical features, pathophysiology and management of PDFS.

Studies suggest that 20–25% of hospitalised dengue patients may develop PDFS, though population-based incidence is likely lower. Risk factors include older age, female sex and possibly host genetic factors.

The hallmark symptom is profound fatigue, often accompanied by musculoskeletal pain, cognitive difficulties, sleep disturbances and mood changes.

While some patients recover within weeks, others experience symptoms persisting for months or years.

The pathophysiology of PDFS remains unclear but may involve persistent immune activation, hypothalamic-pituitary-adrenal axis dysfunction and autonomic nervous system disturbances.

Diagnosis is based on the clinical history and exclusion of alternative causes.

Management typically involves a multidisciplinary approach, including patient education, graded exercise therapy, cognitive behavioural therapy and symptomatic treatment. However, evidence for specific interventions is limited.

Prognosis is variable, with some patients experiencing prolonged disability.

Significant research gaps remain, including the need for standardised diagnostic criteria, biomarkers and controlled trials of potential therapies.

As dengue’s global burden increases, further investigation of PDFS is crucial to improve recognition and develop evidence-based treatments for this impactful sequela of dengue infection.

Keywords
Post-dengue fatigue syndrome
Dengue
Fatigue syndrome
Post-viral

 

GET and CBT, these researchers have a lot to learn from ME/CFS researchers. (GET/CBT excluded of course)

 

"We've got a lot of theories, but not a lot of evidence". And by limited they mean it's made-up and there's basically none.

Somehow, trying the same thing millions of times over and getting the same (negative) results just doesn't bother anyone over there. The lights never turn on, it's completely empty and dark inside those heads.