Psychogenic Non-epileptic Seizures and Pseudo-Refractory Epilepsy, a Management Challenge, 2020, Anzellotti et al

Andy · Jun 26, 2020

Psychogenic nonepileptic seizures (PNES) are neurobehavioral conditions positioned in a gray zone, not infrequently a no-man land, that lies in the intersection between Neurology and Psychiatry. According to the DSM 5, PNES are a subgroup of conversion disorders (CD), while the ICD 10 classifies PNES as dissociative disorders.

The incidence of PNES is estimated to be in the range of 1.4–4.9/100,000/year, and the prevalence range is between 2 and 33 per 100,000. The International League Against Epilepsy (ILAE) has identified PNES as one of the 10 most critical neuropsychiatric conditions associated with epilepsy. Comorbidity between epilepsy and PNES, a condition leading to “dual diagnosis,” is a serious diagnostic and therapeutic challenge for clinicians.

The lack of prompt identification of PNES in epileptic patients can lead to potentially harmful increases in the dosage of anti-seizure drugs (ASD) as well as erroneous diagnoses of refractory epilepsy. Hence, pseudo-refractory epilepsy is the other critical side of the PNES coin as one out of four to five patients admitted to video-EEG monitoring units with a diagnosis of pharmaco-resistant epilepsy is later found to suffer from non-epileptic events. The majority of these events are of psychogenic origin. Thus, the diagnostic differentiation between pseudo and true refractory epilepsy is essential to prevent actions that lead to unnecessary treatments and ASD-related side effects as well as produce a negative impact on the patient's quality of life.

In this article, we review and discuss recent evidence related to the neurobiology of PNES. We also provide an overview of the classifications and diagnostic steps that are employed in PNES management and dwell on the concept of pseudo-resistant epilepsy.
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Open access, https://www.frontiersin.org/articles/10.3389/fneur.2020.00461/full

rvallee · Jun 26, 2020

The majority of these events are of psychogenic origin
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This is not a valid assertion, it is opinion. There is no evidence for this opinion.

Burn this entire field down and rebuild it from the ground up. If it's common to just make stuff up like that and no one bats an eye there is no need to continue any of this. This kind of stuff is unacceptable in all fields of science except this one.

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Psychogenic Non-epileptic Seizures and Pseudo-Refractory Epilepsy, a Management Challenge, 2020, Anzellotti et al

Andy Committee Member

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Psychogenic Non-epileptic Seizures and Pseudo-Refractory Epilepsy, a Management Challenge, 2020, Anzellotti et al

Andy Committee Member

rvallee Senior Member (Voting Rights)

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