Rehabilitation for post-COVID-19 condition through a supervised exercise intervention: a randomized controlled trial, 2022, Jimeno-Almazán et al

Abstract

Purpose
The aim of the study was to compare the outcomes of patients with post-COVID-19 condition undergoing supervised therapeutic exercise intervention or following the self-management WHO (World Health Organization) rehabilitation leaflet.

Methods
A randomized controlled trial that included 39 participants with post-COVID-19 condition who had a chronic symptomatic phase lasting >12 weeks. Comprehensive medical screening, patient-reported symptoms and cardiorespiratory fitness and muscular strength were assessed. Patients were randomly assigned to a tailored multicomponent exercise program based on concurrent training for eight weeks (2 supervised sessions per week comprised of resistance training combined with aerobic training (Moderate Intensity Variable Training), plus a third day of monitored Light Intensity Continuous Training), or to a control group which followed the WHO guidelines for rehabilitation after COVID-19.

Results
After follow-up, there were changes in physical outcomes in both groups, however, the magnitude of the change pre-post intervention favored the exercise group in cardiovascular and strength markers: VO2max + 5.7%, sit to stand -22.7% and load-velocity profiles in bench press + 6.3%, and half squat + 16.9%, (p<0.05). In addition, exercise intervention resulted in a significantly better quality of life, less fatigue, less depression, and improved functional status, as well as in superior cardiovascular fitness and muscle strength compared to controls (p<0.05). No adverse events were observed during the training sessions.

Conclusion
Compared to current WHO recommendations, a supervised, tailored concurrent training at low and moderate intensity for both resistance and endurance training is a more effective, safe, and well tolerated intervention in post-COVID-19 conditions.

Paywall, https://onlinelibrary.wiley.com/doi/10.1111/sms.14240

 

Fortunately, they have at least some awareness of PEM: