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Renegade Human Genetic Sequences in an African Green Monkey Simian Cytomegalovirus (SCMV): Portending Novel Infectious and Genetic Illnesses
W John Martin1
November 10, 2025 Posted on 10 Nov 2025 CC-BY-NC-ND 4 https://doi.org/10.22541/au.176281856.69732818/v1
This is a preprint and has not been peer-reviewed.
Data may be preliminary.
Institute of Progressive Medicine South Pasadena, CA 91030 Running Title: KELEA Assisted Restoration of Natures Allostasis Author Mailing Address: 1634 Spruce Street, South Pasadena, CA 91030 E-Mail: wjohnmartin@ccid.org Phone: 01-626-616-2868 Author ORCID Number: 0000-0002-9947-4374
Conflicts of Interests: None
Word Count w/o References 1,783
Abbreviations: SCMV- African green monkey simian cytomegalovirus, CFS- chronic fatigue syndrome, lncRNA- long non-coding RNA, PCR- polymerase chain reaction, N- ambiguous nucleotide in genetic sequence, T3 and T7- promoter sites on pBluescript plasmid used for sequencing
Keywords: Renegade sequences, SCMV, polio vaccines, autism, horizontal gene transfer, homologous recombination
Abstract
The cellular immune response to viruses is commonly only directed against a few of the many genetically coded virus components.
This is especially noteworthy with human cytomegalovirus, in which about 90% of the evoked cytotoxic T cells are collectively directed against three of the over two hundred virus-coded proteins.
Stealth adaptation is an immune evasion mechanism in which there is deletion or mutation of the viral genes coding for the major antigens targeted by cellular immunity.
It has occurred with an African green monkey simian cytomegalovirus (SCMV) cultured from a chronic fatigue syndrome (CFS) patient.
DNA cloning of the virus indicated the incorporation into the virus of genetic sequences of cellular and bacterial origin.
The acquired genetic sequences are referred to as renegade because they are away from their normal location.
This article updates the information on the acquired cellular sequences in the stealth adapted virus.
The sequences are human rather than African green monkey, presumably because of homologous recombination.
They comprise genetically unstable, non-coding sequences either from within the introns of the identi ed genes or from intergenic sequences.
Renegade cellular genetic sequences have the potential to cause new types of infectious gene-mediated illnesses.
