From this PR open thread:
https://forums.phoenixrising.me/thr...-syndrome-m-baraniuk-2022.86742/#post-2390443
“Those of you with long memories will remember that Pyrrhus' second diagram of "the ascending arousal network" is the same network that led to some of the hypothesized consequences of the IDO1 metabolic trap in the Raphe nucleus. But that's not why I'm writing this post. The combination of recent successes 1) from surgical correction of CCI and, 2) from stellate ganglion block, have drawn me back to the midbrain. I'm still working on the itaconate metabolic trap as my day job, but there's a useful concept called night-science when you are free to work on something new that feels important - and right now, my night-science is focused on the possibility of bistabilities in brainstem neural circuits. I could use some help. What I want to find is the best, most detailed diagram of the brainstem connectome that's available. I've been to the Allen Brain Institute site and got lost somewhere around the hypothalamus. Modern neuroscience appears fixated on the cerebral cortex, but there is a lot that we (or at least I) do not understand about the organization of the brainstem, what neurons project where, and what neurotransmitters are crossing those synapses. If all the smart people on PR would send me the one or two best diagrams they can find in an hour of searching, I'd really appreciate your help. Thanks.”
https://forums.phoenixrising.me/thr...-syndrome-m-baraniuk-2022.86742/#post-2390443
“Those of you with long memories will remember that Pyrrhus' second diagram of "the ascending arousal network" is the same network that led to some of the hypothesized consequences of the IDO1 metabolic trap in the Raphe nucleus. But that's not why I'm writing this post. The combination of recent successes 1) from surgical correction of CCI and, 2) from stellate ganglion block, have drawn me back to the midbrain. I'm still working on the itaconate metabolic trap as my day job, but there's a useful concept called night-science when you are free to work on something new that feels important - and right now, my night-science is focused on the possibility of bistabilities in brainstem neural circuits. I could use some help. What I want to find is the best, most detailed diagram of the brainstem connectome that's available. I've been to the Allen Brain Institute site and got lost somewhere around the hypothalamus. Modern neuroscience appears fixated on the cerebral cortex, but there is a lot that we (or at least I) do not understand about the organization of the brainstem, what neurons project where, and what neurotransmitters are crossing those synapses. If all the smart people on PR would send me the one or two best diagrams they can find in an hour of searching, I'd really appreciate your help. Thanks.”
