Respiratory Chain Enzyme Function Analysis in ME?

[Rossy191276]

Does anybody know if researchers have done any respiratory chain enzyme function analysis studies using muscle tissue in ME?

The mitochondrial disease doctor I saw said that it is a way to diagnose genetic mito but I would think that respiratory chain enzyme dysfunction could be a secondary result to potential ME factors as well...my scientific knowledge is very limited so would be happy for those of you with better understanding of these processes to give thoughts...

Thanks

 

[Mij]

I'm not sure if any researcher has performed this test using muscle tissue. Ron Davis Mitochondrial Function Test using SeaHorse instrument is part of his menu. It's a technology that allows researchers to determine energy consumption of cells. The amount of O2 present indicates how much energy is being produced through glycolysis and by the mito.

You can read about it here.

 

[Rossy191276]

I'm not sure if any researcher has performed this test using muscle tissue. Ron Davis Mitochondrial Function Test using SeaHorse instrument is part of his menu. It's a technology that allows researchers to determine energy consumption of cells. The amount of O2 present indicates how much energy is being produced through glycolysis and by the mito.

You can read about it here.

Thank you @Mij

I assume then that Ron Davis did these tests as part of severely ill study...Do you know if he has talked about results of this test anywhere?

 

[Mij]

@Rossy191276 I don't but you could ask on PR, Janet Dafoe might have some information.