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Robust Neutralizing Antibody Levels Detected after Either SARS-CoV-2 Vaccination or One Year after Infection 2021 Glöckner et al

Discussion in 'Epidemics (including Covid-19, not Long Covid)' started by Andy, Jan 19, 2023.

  1. Andy

    Andy Committee Member

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    Abstract

    Humoral immunity after infection or after vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been attributed a key part in mitigating the further transmission of the virus. In this study, we used a commercial anti-Spike immunoglobulin G (S-IgG) assay and developed a cell culture-based neutralization assay to understand the longitudinal course of neutralizing antibodies in both SARS-CoV2 infected or vaccinated individuals.

    We show that even more than one year after infection, about 78% of observed study participants remained seropositive concerning S-IgG antibodies. In addition, the serum of the individuals had stable neutralization capacity in a neutralization assay against a SARS-CoV-2 patient isolate from March 2020.

    We also examined volunteers after either homologous BNT162b2 prime-boost vaccination or heterologous AZD1222 prime/mRNA-based booster vaccination. Both the heterologous and the homologous vaccination regimens induced higher levels of neutralizing antibodies in healthy subjects when compared to subjects after a mild infection, showing the high effectiveness of available vaccines. In addition, we could demonstrate the reliability of S-IgG levels in predicting neutralization capacity, with 94.8% of seropositive samples showing a neutralization titer of ≥10, making it a viable yet cheap and easy-to-determine surrogate parameter for neutralization capacity.

    Open access, https://www.mdpi.com/1999-4915/13/10/2003
     
    Last edited by a moderator: Jan 19, 2023
    Andy, Jan 19, 2023
    #1
    Peter Trewhitt and Trish like this.
  2. rvallee

    rvallee Senior Member (Voting Rights)

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    This would be good news if it weren't for the fact that variants spread was turbocharged so much that being immune to one strain barely makes a difference anymore, everyone everywhere is in a soup of multiple variants that will keep changing and have changed so much newer variants are as far removed from SARS-CoV-2 as it was from SARS-1.

    Seems like a lot was bet on the idea that immunity is to a virus, even though we have to deal with the flu variants every year. Ignoring evolutionary forces while maximizing them, what a failure.
     
    rvallee, Jan 19, 2023
    #2
    Hutan, Trish and alktipping like this.
  3. Hutan

    Hutan Moderator Staff Member

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    Is that true?
     
    Hutan, Jan 20, 2023
    #3
  4. rvallee

    rvallee Senior Member (Voting Rights)

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    It was pretty much inevitable the moment it was decided to let it rip. Still the same virus, but variations and recombinations add up and we're doing a whole lot of adding up.

    [​IMG]
     
    rvallee, Jan 20, 2023
    #4
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  5. CRG

    CRG Senior Member (Voting Rights)

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    CRG, Jan 20, 2023
    #5
  6. Hutan

    Hutan Moderator Staff Member

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    @rvallee, is that chart illustrating just one aspect of the viruses e.g. the spike protein? I had read that SARS-CoV-2 was closest to a bat virus except that a part of it, the spike if I'm, remembering correctly, was closest to a pangolin virus. The chart above doesn't appear to mention the bat virus, but has what I assume is an early version of SARS-CoV-2 very close to a pangolin virus.

    So, it may be that part of the virus has mutated rapidly and now looks quite different to the first strain. But I'd surprised if GD Pangolin was actually, in its entirety, almost identical to the first strain, but later versions of SARS-CoV-2 are, in their entirety, so much different.

    That doesn't invalidate your argument that the vaccinations and the antibodies they generate are probably pretty useless by now, with the virus having mutated around the proteins that the vaccinations targeted.
     
    Hutan, Jan 20, 2023
    #6
  7. rvallee

    rvallee Senior Member (Voting Rights)

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    Not sure how it's assessed but I think it's kind of a "diff" on two versions that check for how many differences there are, whether they are significant or not, but the more differences there are, the less likely past immunity is likely to nip it in the bud.
     
    rvallee, Jan 21, 2023
    #7

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