https://neurosciencenews.com/schizophrenia-synaptic-plasticity-27616/ Summary: Researchers have identified a mechanism that impairs synaptic plasticity in individuals with schizophrenia, revealing the role of three key proteins. Using computational modeling, the team explored how genetic alterations affect the brain’s ability to strengthen or weaken synaptic connections, a crucial process for memory and learning. This breakthrough offers a new understanding of how genetic variants linked to schizophrenia contribute to the disorder’s symptoms and points toward potential targets for future treatments. The findings could lead to new insights into the development of schizophrenia and improved therapeutic strategies. Key Facts: Three key proteins linked to synaptic plasticity are impaired in schizophrenia. Computational models predict how genetic changes affect brain connections. The study opens up possibilities for new schizophrenia treatments targeting these proteins. Paper - closed access https://www.pnas.org/doi/10.1073/pnas.2312511121
Interesting not well enough to read until a good day but off top of head it sounds feasible (but then all the bps stuff aims to tick that box so I know it’s the rest that counts)
