Science: The immunology and immunopathlogy of COVID-19, Merad, Iwasaki et al, 2022

Abstract

Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms after disease resolution.

We review the results of almost 2 years of COVID-19 immunology research and discuss definitive findings and remaining questions regarding our understanding of COVID-19 pathophysiology.

We discuss emerging understanding of differences in immune responses seen in those with and without Long Covid syndrome, also known as post-acute sequelae of SARS-CoV-2.

We hope that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need.

https://www.science.org/doi/10.1126/science.abm8108

 

The latest edition of Science is a special issue titled: COVID-19: 2 years on

On 11 March 2020, the World Health Organization officially characterized COVID-19 as a pandemic, triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Science marks this anniversary with a special issue that highlights the international scientific community’s extraordinary achievements in response to the pandemic—and, as SARS-CoV-2 becomes endemic, outlines ways to bridge the gaps in our understanding of this changing virus and our responses to it.

https://www.science.org/toc/science/current