Nitric Oxide (NO), though small and labile, is a potent signaling molecule that plays important roles in both normal physiological function, as well as disease initiation and progression. Both lack and excess NO have been revealed as a contributing factor in pathophysiology in nearly all organs of the body. https://www.frontiersin.org/researc...to-study-no-and-rns-in-physiology-and-disease
Breathing through the nose instead of the mouth has many benefits, including increasing the release of nitric oxide from the sinuses.