Preprint Stress-Related Chronic Fatigue Syndrome: A Case Report with Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment, 2024, Ljungström

https://www.preprints.org/manuscript/202406.1544/v1

Stress-Related Chronic Fatigue Syndrome: A Case Report with Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment
Maria Ljungström
Elisa Oltra
Marta Pardo
*

Version 1 : Received: 21 June 2024 / Approved: 21 June 2024 / Online: 21 June 2024

How to cite: Ljungström, M.; Oltra, E.; Pardo, M. Stress-Related Chronic Fatigue Syndrome: A Case Report with Positive Response to Alpha-Methyl-P-Tyrosine (AMPT) Treatment. Preprints 2024, 2024061544.

Abstract

Alpha-methyl-p-tyrosine (AMPT; also referred as metyrosine) is an approved medication for the treatment of pheochromocytoma.

As a tyrosine hydroxylase inhibitor AMPT may be a potential candidate for the treatment of diseases involving catecholamine alterations.

However, only small-scale clinical trials have tested AMPT repurposing in few other illnesses.

Chronic fatigue syndrome (CFS) is an heterogenous disorder with genetically associated vulnerability of catecholamine metabolism (e.g. catechol O-methyltransferase polymorphisms) holding an important impact of environmental factors.

The current case report compiles genetic and longitudinal biochemical data for over a year follow-up of one patient sequentially diagnosed with sustained overstress, neurasthenia, CFS, and POTS (postural orthostatic tachycardia syndrome) over a 10-year period, and reports patient’s symptom improvement in response to low-medium doses of AMPT.