Study links environmental phenols to changes in heart electrical activity

[Sly Saint]

Environmental phenols are found in a wide range of common consumer products. They include preservatives in packaged foods, parabens in shampoos and bisphenol A (BPA) in plastic dishware, so humans have broad exposure to them, day in and day out.

Some of these environmental phenols are known to have cardiac toxicities. Now, an interdisciplinary study involving four University of Cincinnati College of Medicine professors is revealing their adverse impact on the heart's electrical properties, and the research has been published in the journal Environmental Health.

This is the first study to look at the impact of phenol exposure on cardiac electrical activity in humans."

Hong-Sheng Wang, PhD, Professor in the Department of Pharmacology, Physiology and Neurobiology and study's lead author

Researchers used data from the Fernald Community Cohort, which includes nearly 10,000 people who lived near the former U.S. Department of Energy uranium processing site at Fernald, outside Cincinnati, and participated in the Fernald Medical Monitoring Program between 1990 and 2008.

The research concluded higher exposure to some environmental phenols is associated with altered cardiac electrical activity.

Researchers found higher exposure to BPA, BPF and BPA+F in women is associated with a longer PR interval, a delay in the time it takes for electrical signals to move from the atria at the top of the heart to the ventricles.

"Our findings were highly sex-specific," said Wang. In women, researchers identified an association with longer QRS duration, or contraction of the ventricles, and dysfunction of the electrical impulses of the heart.

"It was particularly pronounced in women with higher body mass indexes," said Wang.

In men, researchers found higher exposure to triclocarban (TCC), an antimicrobial agent, led to longer QT intervals in the heart -; meaning the heart's electrical system is taking too long to recharge, a situation that can contribute to heart rhythm dysfunction. TCC has since been banned in the United States.

Wang also pointed out that typical exposure levels alone are unlikely to cause clinically significant heart disease in healthy people.

"These were not dramatic changes that we observed, but moderate changes to cardiac electrical activity," he said. "However, they were particularly pronounced in certain subpopulations."

He said the altered cardiac activity could exacerbate existing heart disease or arrhythmias in a patient, especially older adults or those with other risk factors.

"Now there are new chemicals out there, so the next step would be to examine these newer environmental chemicals and to focus on their impact on an individual level in those who are predisposed to heart disease," said Wang.

Other contributors in this study included Susan Pinney, PhD, FACE, professor of epidemiology in the Department of Environmental and Public Health Sciences; Jack Rubinstein, MD, FACC, professor of clinical cardiology in the Department of Internal Medicine; and Changchun Xie, PhD, professor in the Department of Biostatistics, Health Informatics and Data Sciences.

This study was funded by grants from the National Institute of Environmental Health and the University of Cincinnati Center for Environmental Genetics.

Source:

University of Cincinnati

Journal reference:

Rubinstein, J., et al. (2024). Association of same-day urinary phenol levels and cardiac electrical alterations: analysis of the Fernald Community Cohort. Environmental Health. doi.org/10.1186/s12940-024-01114-x.

Study links environmental phenols to changes in heart electrical activity (msn.com)