Thread here on PEM may be of interest in considering guidelines. https://www.s4me.info/threads/is-pem-cumulative-public-thread.7922/page-3#post-140017 In particular two studies are mentioned (one a follow-up of the first). https://www.s4me.info/threads/is-pem-cumulative-public-thread.7922/#post-139710 The studies are: Time course of exercise induced alterations in daily activity in chronic fatigue syndrome (2005) Christopher D Black and Kevin K McCully https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1280928/ Increased daily physical activity and fatigue symptoms in chronic fatigue syndrome (2005) Christopher D Black, Patrick J O'Connor, and Kevin K McCully https://www.ncbi.nlm.nih.gov/pmc/articles/PMC555551/