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Synbiotic Supplementation Improves Quality of Life and Inmunoneuroendocrine Response in Patients with FM: 2023 Hinchado et al

Discussion in ''Conditions related to ME/CFS' news and research' started by Andy, Apr 14, 2023.

  1. Andy

    Andy Committee Member

    Messages:
    22,394
    Location:
    Hampshire, UK
    Full title: Synbiotic Supplementation Improves Quality of Life and Inmunoneuroendocrine Response in Patients with Fibromyalgia: Influence of Codiagnosis with Chronic Fatigue Syndrome

    Fibromyalgia (FM) and chronic fatigue syndrome (CFS) are two medical conditions in which pain, fatigue, immune/inflammatory dysregulation, as well as various mental health disorders predominate in the diagnosis, without evidence of a clear consensus on the treatment of FM and CFS.

    The main aim of this research was to analyse the possible effects of a synbiotic (Synbiotic, Gasteel Plus® (Heel España S.A.U.), through the study of pro-inflammatory/anti-inflammatory cytokines (IL-8/IL-10) and neuroendocrine biomarkers (cortisol and DHEA), in order to evaluate the interaction between inflammatory and stress responses mediated by the cytokine-HPA (hypothalamic-pituitary-adrenal) axis, as well as mental and physical health using body composition analysis, accelerometry and previously validated questionnaires. The participants were women diagnosed with FM with or without a diagnostic of CFS.

    Each participant was evaluated at baseline and after the intervention, which lasted one month. Synbiotic intervention decreased levels of perceived stress, anxiety and depression, as well as improved quality of life during daily activities. In addition, the synbiotic generated an activation of HPA axis (physiological cortisol release) that can compensate the increased inflammatory status (elevated IL-8) observed at baseline in FM patients. There were no detrimental changes in body composition or sleep parameters, as well as in the most of the activity/sedentarism-related parameters studied by accelerometry.

    It is concluded that synbiotic nutritional supplements can improve the dysregulated immunoneuroendocrine interaction involving inflammatory and stress responses in women diagnosed with FM, particularly in those without a previous CFS diagnostic; as well as their perceived of levels stress, anxiety, depression and quality of life.

    Open access, https://www.mdpi.com/2072-6643/15/7/1591
     
    Andy, Apr 14, 2023
    #1
    Peter Trewhitt, shak8 and Hutan like this.
  2. Hutan

    Hutan Moderator Staff Member

    Messages:
    27,984
    Location:
    Aotearoa New Zealand
    So, a large proportion of people with FM have CFS. And higher levels of cortisol are characteristic of FM (and, by extension, CFS). But wait - higher cortisol? Wasn't it supposed to be lower cortisol? Or lower cortisol before breakfast? Or something? People are so sure these conditions have something to do with stress, that surely they have to do something to cortisol.

    Commercial product
    Sample
    15 women, 7 also with CFS
    So, small, and no healthy controls for comparisons

    Outcomes - so many
    Including two new ones for us:
    COVID-19 questionnaires:
    • CAS (Coronavirus Anxiety Scale). The higher the score, the greater the sense of anxiety. Higher scores are related to higher anxiety towards COVID-19 [26].
    • FCV-19S (Fear of Coronavirus). The higher the score, the greater the sense of fear of the coronavirus [27].
     
    Hutan, Apr 14, 2023
    #2
    RedFox, Peter Trewhitt and shak8 like this.
  3. Trish

    Trish Moderator Staff Member

    Messages:
    53,649
    Location:
    UK
    Fukuda criteria used for CFS, so likely many are primarily FM with enough overlapping symptoms to satisfy Fukuda, but not necessarily having PEM.
    A quick glance at the actimetry seems to suggest they all became less active.
     
    Trish, Apr 14, 2023
    #3
    RedFox, alktipping, Peter Trewhitt and 1 other person like this.
  4. NelliePledge

    NelliePledge Moderator Staff Member

    Messages:
    13,914
    Location:
    UK West Midlands
    For anyone else who hadn’t heard the term synbiotic before here’s info from Wikipedia https://en.wikipedia.org/wiki/Synbiotics

    To be honest I had initially read it as symbiotic and thought they had been watching too much Stargate :whistle:
     
    NelliePledge, Apr 14, 2023
    #4
    shak8, alktipping and Trish like this.

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