T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease, 2019, Petersen et al

Andy · Jan 8, 2020

The human leukocyte antigen (HLA) locus is strongly associated with T cell-mediated autoimmune disorders. HLA-DQ2.5-mediated celiac disease (CeD) is triggered by the ingestion of gluten, although the relative roles of genetic and environmental risk factors in CeD is unclear.

Here we identify microbially derived mimics of gliadin epitopes and a parental bacterial protein that is naturally processed by antigen-presenting cells and activated gliadin reactive HLA-DQ2.5-restricted T cells derived from CeD patients. Crystal structures of T cell receptors in complex with HLA-DQ2.5 bound to two distinct bacterial peptides demonstrate that molecular mimicry underpins cross-reactivity toward the gliadin epitopes. Accordingly, gliadin reactive T cells involved in CeD pathogenesis cross-react with ubiquitous bacterial peptides, thereby suggesting microbial exposure as a potential environmental factor in CeD.
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Paywall, https://www.nature.com/articles/s41594-019-0353-4
Sci hub, https://sci-hub.se/10.1038/s41594-019-0353-4

Andy · Jan 8, 2020

Article

Bacterial exposure has been identified as a potential environmental risk factor in developing coeliac disease, a hereditary autoimmune-like condition that affects about one in 70 Australians.
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https://medicalxpress.com/news/2020-01-bacterial-link-celiac-disease.html

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T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease, 2019, Petersen et al

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T cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease, 2019, Petersen et al

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