Hypertension not MECFS, but pretty interesting.
Highlights
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The serum α-lipomycin level and fecal mRNA level of LipReg4 are elevated in HSD mice
•
S. aureofaciens Tü117 increases the serum α-lipomycin concentration and BPs in mice
•
α-lipomycin impairs vasodilation and increases BPs relying on endothelial TRPV4
•
L. plantarum CCFM639 reduces BPs involving inhibition against S. aureofaciens Tü117
Summary
Currently, the regulation of specific gut microbial metabolism for the development and/or treatment of hypertension remains largely unexplored. Here, we show that α-lipomycin, produced by Streptomyces aureofaciens (S. aureofaciens) Tü117, is upregulated in the serum of high-salt diet (HSD) mice and patients with essential hypertension. α-lipomycin causes vasodilation impairment involving transient receptor potential vanilloid 4 (TRPV4)-mediated nitric oxide and endothelium-derived hyperpolarizing factor pathways in mice. We also find that Lactobacillus plantarum (L. plantarum) CCFM639 attenuates the increase in blood pressure (BP) potentially through inhibiting the proliferation of S. aureofaciens Tü117 in mice. An exploratory intervention trial indicates that L. plantarum CCFM639 supplementation reduces BPs in subjects newly diagnosed with pre-hypertension or stage 1 hypertension without antihypertensive medication. Our findings provide evidence for a role of S. aureofaciens Tü117-associated α-lipomycin elevation in the pathogenesis of HSD-induced hypertension, highlighting that targeting gut bacteria serves as a new therapeutic intervention for hypertension.
Graphical abstract
https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00004-X
Highlights
•
The serum α-lipomycin level and fecal mRNA level of LipReg4 are elevated in HSD mice
•
S. aureofaciens Tü117 increases the serum α-lipomycin concentration and BPs in mice
•
α-lipomycin impairs vasodilation and increases BPs relying on endothelial TRPV4
•
L. plantarum CCFM639 reduces BPs involving inhibition against S. aureofaciens Tü117
Summary
Currently, the regulation of specific gut microbial metabolism for the development and/or treatment of hypertension remains largely unexplored. Here, we show that α-lipomycin, produced by Streptomyces aureofaciens (S. aureofaciens) Tü117, is upregulated in the serum of high-salt diet (HSD) mice and patients with essential hypertension. α-lipomycin causes vasodilation impairment involving transient receptor potential vanilloid 4 (TRPV4)-mediated nitric oxide and endothelium-derived hyperpolarizing factor pathways in mice. We also find that Lactobacillus plantarum (L. plantarum) CCFM639 attenuates the increase in blood pressure (BP) potentially through inhibiting the proliferation of S. aureofaciens Tü117 in mice. An exploratory intervention trial indicates that L. plantarum CCFM639 supplementation reduces BPs in subjects newly diagnosed with pre-hypertension or stage 1 hypertension without antihypertensive medication. Our findings provide evidence for a role of S. aureofaciens Tü117-associated α-lipomycin elevation in the pathogenesis of HSD-induced hypertension, highlighting that targeting gut bacteria serves as a new therapeutic intervention for hypertension.
Graphical abstract
https://www.cell.com/cell-metabolism/abstract/S1550-4131(25)00004-X