Tech boss uses AI and ChatGPT to create cancer vaccine for his dying dog

Business-section article in a Murdoch-owned paper, shared by Ajit Pai, full of "scientists" desperately glazing a tech-bro entrepreneur, lamenting the pesky "ethics" requirements holding back the brilliance of untrained would-be "researchers" and heralding ChatGPT as both a great democratizing force and the future of medicine.

I'm all for additional research into mRNA vaccines, but with regard to the details of this particular situation and its larger relevance, press F to doubt, as I believe the children used to say.
 
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“Sorry to be the downer because this is an impressive story in some senses.

But it is ~trivially easy to make a single mRNA vaccine. It's not hard.

I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year.

What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade.

I am happy for this man and his dog. It is impressive.

But y'all are overhyping it.”
 


“Sorry to be the downer because this is an impressive story in some senses.

But it is ~trivially easy to make a single mRNA vaccine. It's not hard.

I cure mice of various cancers with various therapeutics all the time. I've made mice lose more weight in a month than tirzepatide does in a year.

What is hard and expensive is proving its BOTH safe AND effective **in a randomized and controlled study in humans** while ALSO manufacturing it at clinical scale and grade.

I am happy for this man and his dog. It is impressive.

But y'all are overhyping it.”

That seems familiar. I've heard stories like this happening in mice on the news my whole life without ever leading anywhere. Or will our AI overlords publish these so promising results?
 



“The story about bureaucracy almost stopping a man from treating his dog’s cancer with an mRNA vaccine went viral.

The problem transfers to humans: we’ve made these clinical trials unnecessarily hard, denying hope to patients.

New article on this.”
 
Last post on the dog that wasn’t really cured.




According to the story, the dog's cancer has not been cured.
• Absent all regulatory and manufacturing constraints, we could not just synthesize magic mRNA cancer cures. The technology is very promising, but it's not yet any kind of panacea.
• The emergent system of regulators and manufacturers is indeed far too conservative, and small-scale experimentation is much harder than it should be. More people should read the first part of The Rise and Fall of Modern Medicine. Recommend @RuxandraTeslo, @PatrickHeizer for more.”
 
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