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The effect of donepezil hydrochloride on post-COVID memory impairment: A randomized controlled trial, 2023, Pooladgar et al

Discussion in 'Long Covid research' started by EndME, Nov 13, 2023.

  1. EndME

    EndME Senior Member (Voting Rights)

    Messages:
    1,094
    The effect of donepezil hydrochloride on post-COVID memory impairment: A randomized controlled trial



    Abstract

    Background:     Post-Coronavirus Disease (COVID-19) condition, known as "post-COVID syndrome," is associated with a range of complications persisting even after recovery. Among these complications, cognitive dysfunction, including memory impairment, has been relatively common observed, impacting executive function and quality of life. To date, no approved treatment exists for this specific complication. Therefore, the present clinical trial aimed to investigate the impact of Donepezil Hydrochloride on post-COVID memory impairment.

    Methods: A randomized, controlled trial (Approval ID: IRCT20210816052203N1) was conducted, enrolling 25 patients with post-COVID memory impairment. Participants with a history of hospitalization were randomly assigned to either the drug group (n = 10) or the control group (n = 15). Memory indices were assessed at baseline, one month, and three months later using the Wechsler Memory Scale-Revised test. SPSS software and appropriate statistical tests were employed for data analysis.

    Results: The statistical analysis revealed no significant difference in WMS-R subtest and index scores between the drug and control groups at the 4-week and 12-week follow-up periods. However, within the drug group, there was a notable increase in the visual reproduction I and verbal paired associates II subtests during the specified time intervals.

    Conclusion: While donepezil 5 mg did not exhibit a significant overall increase in memory scales compared to the control group over time, our findings suggest that this medication may exert a positive effect on specific memory subtests. Further research and exploration are warranted to better understand the potential benefits of donepezil in managing post-COVID-related memory impairment.

    https://pubmed.ncbi.nlm.nih.gov/37952347/
     
    EndME, Nov 13, 2023
    #1
    Ash, Sean, RedFox and 2 others like this.
  2. Trish

    Trish Moderator Staff Member

    Messages:
    53,662
    Location:
    UK
    The full text doesn't seem to be open access. It might be interesting to see a table of data.

    Given that there was no between group difference on any of the subscores, it must be irrelevant that there was a within group change on a couple of scores. That surely means the control group also improved on those scores, so the drug has not been shown to have any effect.

    Looks like a case of cherry picking, presumably so they can try to justify getting funding to do further research.
     
    Trish, Nov 13, 2023
    #2
    RedFox, alktipping, Hutan and 2 others like this.
  3. Caroline Struthers

    Caroline Struthers Senior Member (Voting Rights)

    Messages:
    927
    Location:
    Oxford UK
    It is not worth doing a trial with less than 100 participants, and even that's too small in my opinion. Even if there were a difference between the two groups (which there isn't) the study isn't adequately powered from the start. Absolute garbage, as per
     
    Caroline Struthers, Nov 13, 2023
    #3
    alktipping, Hutan, shak8 and 1 other person like this.
  4. Hutan

    Hutan Moderator Staff Member

    Messages:
    27,994
    Location:
    Aotearoa New Zealand
    I wouldn't go so far as to say 100 participants are needed, but yes, 10 for the treatment group is just hopeless.

    It's worse than that, because these people had been hospitalised with Covid-19. So, there are reasons other than PCS why they might be having cognitive dysfunction. If you only have 10 people given the drug and one of those was developing dementia anyway, and a couple are suffering from brain damage due to a lack of oxygen during their acute disease, even a moderate effect will be buried in noise.
     
    Hutan, Nov 13, 2023
    #4
    Ash, EndME, alktipping and 3 others like this.
  5. Sean

    Sean Moderator Staff Member

    Messages:
    7,608
    Location:
    Australia
    Post-Coronavirus Disease
    post-COVID syndrome

    Coz there just isn't enough acronyms. :rolleyes:
     
    Sean, Nov 14, 2023
    #5
    Ash and Trish like this.

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