The immune system can sabotage gene therapies — can scientists rein it in?

People treated with gene therapy cannot receive a second dose for fear of a dangerous immune response. Researchers hope to find a way around this.

To their surprise, a second dose of the gene therapy was nevertheless effective against the respiratory ailment. It’s a mystery why the approach worked despite the residual immune responses, says Kang, but might have something to do with the fact that the therapy was administered directly into the lungs, rather than the bloodstream.

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