The Kynurenine connection: how exercise shifts muscle tryptophan metabolism & affects energy homeostasis, the immune system & the brain, 2020, Martin

Andy · Mar 28, 2020

Tryptophan catabolism through the kynurenine pathway generates a variety of bioactive metabolites. Physical exercise can modulate kynurenine pathway metabolism in skeletal muscle, and thus change the concentrations of select compounds in peripheral tissues and in the central nervous system. Here we review recent advances in our understanding of how exercise alters tryptophan-kynurenine metabolism in muscle and its subsequent local and distal effects.

We propose that the effects of kynurenine pathway metabolites on skeletal muscle, adipose tissue, immune system, and the brain, suggest that some of these compounds could qualify as exercise-induced myokines. Indeed, some of the more recently discovered biological activities for kynurenines include many of the best-known benefits of exercise: improved energy homeostasis, promotion of an anti-inflammatory environment, and neuroprotection. Finally, by considering the tissue expression of the different membrane and cytosolic receptors for kynurenines
Click to expand...

Paywall, https://journals.physiology.org/doi/abs/10.1152/ajpcell.00580.2019
Sci-hub not available at time of posting.

Log in or Sign up

The Kynurenine connection: how exercise shifts muscle tryptophan metabolism & affects energy homeostasis, the immune system & the brain, 2020, Martin

Andy Committee Member

Share This Page

Log in or Sign up

The Kynurenine connection: how exercise shifts muscle tryptophan metabolism & affects energy homeostasis, the immune system & the brain, 2020, Martin

Andy Committee Member

Share This Page

Useful Searches