https://www.sciencedirect.com/science/article/pii/S2001037023002775 Computational and Structural Biotechnology Journal Available online 5 August 2023 Mini-Review The Microbiome in Post-Acute Infection Syndrome (PAIS) Author links open overlay panel, , , a Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, USA b School of Public Health, Sun Yat-Sen University, Guangzhou, China c School of Public Health, Xinjiang Medical University, Urumqi, China d Hainan Key Novel Thinktank “Hainan Medical University ‘One Health’ Research Center”, Haikou, China Received 12 May 2023, Revised 3 August 2023, Accepted 3 August 2023, Available online 5 August 2023. https://doi.org/10.1016/j.csbj.2023.08.002 ABSTRACT Post-Acute Infection Syndrome (PAIS) is a relatively new medical terminology that represents prolonged sequelae symptoms after acute infection by numerous pathogenic agents. Imposing a substantial public health burden worldwide, PASC (post-acute sequelae of COVID-19 infection) and ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) are two most recognized and prevalent PAIS conditions. The presences of prior infections and similar symptom profiles in PAIS reflect a plausible common etiopathogenesis. The human microbiome is known to play an essential role in health and disease. In this review, we reviewed and summarized available research on oral and gut microbiota alterations in patients with different infections or PAIS conditions. We discussed key theories about the associations between microbiome dysbiosis to PAIS disease development, aiming to explore the mechanistic roles and potential functions the microbiome may have in the process. Additionally, we discuss the areas of knowledge gaps and propose the potential clinical applications of the microbiome for prevention and treatment of PAIS conditions. Keywords Post-Acute Infection Syndromes microbiome PASC ME/CFS
Does it really? They don't seem burdened by it at all. Certainly not enough to do anything about it. Expensive, yeah. Especially ignoring it. But burdened? Not really, or they'd actually do something, pay attention and stop denying at the very least.
