The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report, 2024, Yamamoto et al.

[SNT Gatchaman]

The perivascular space is a conduit for cerebrospinal fluid flow in humans: A proof-of-principle report
Yamamoto, Erin A.; Bagley, Jacob H.; Geltzeiler, Mathew; Sanusi, Olabisi R.; Dogan, Aclan; Liu, Jesse J.; Piantino, Juan

The glymphatic pathway was defined in rodents as a network of perivascular spaces (PVSs) that facilitates organized distribution of cerebrospinal fluid (CSF) into the brain parenchyma. To date, perivascular CSF and cerebral interstitial fluid exchange has not been shown in humans. Using intrathecal gadolinium contrast-enhanced MRI, we show that contrast-enhanced CSF moves through the PVS into the parenchyma, supporting the existence of a glymphatic pathway in humans.

Link | PDF (Proceedings of the National Academy of Sciences) [Open Access]

 

[SNT Gatchaman]

This case series emphasizes several findings: 1) dynamic PVS visualization in humans with intrathecal/subarachnoid gadolinium based contrast is best captured by serial T2/FLAIR imaging; 2) contrast-enhanced CSF flows centripetally from subarachnoid space to parenchyma along the PVS; 3) PVS are involved in CSF influx and are not stagnant fluid-filled structures. These findings support a PVS network in humans that facilitates the distribution of CSF into the brain parenchyma

 

[Ash]

I don’t know what any of these words mean. Is this interesting to people who do?
What would the implications be?