Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity, 2020, Anhe et al

Andy · Mar 10, 2020

Visceral obesity is a key risk factor for type 2 diabetes (T2D). Whereas gut dysbiosis appears to be instrumental for this relationship, whether gut-associated signatures translocate to extra-intestinal tissues and how this affects host metabolism remain elusive. Here we provide a comparative analysis of the microbial profile found in plasma, liver and in three distinct adipose tissues of individuals with morbid obesity.

We explored how these tissue microbial signatures vary between individuals with normoglycaemia and those with T2D that were matched for body mass index. We identified tissue-specific signatures with higher bacterial load in the liver and omental adipose tissue. Gut commensals, but also environmental bacteria, showed tissue- and T2D-specific compartmentalisation. T2D signatures were most evident in mesenteric adipose tissue, in which individuals with diabetes displayed reduced bacterial diversity concomitant with fewer Gram-positive bacteria, such as Faecalibacterium, as opposed to enhanced levels of typically opportunistic Gram-negative Enterobacteriaceae. Plasma samples of individuals with diabetes were similarly enriched in Enterobacteriaceae, including the pathobiont Escherichia–Shigella.

Our work provides evidence for the presence of selective plasma and tissue microbial signatures in individuals with severe obesity and identifies new potential microbial targets and biomarkers of T2D.
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Open access, https://www.nature.com/articles/s42255-020-0178-9

Cinders66 · Mar 12, 2020

Merged thread
Bacteria found leaking from gut to body in people who are obese

http://bit.ly/2wNjimt

i don’t know if it’s correlation or causation as I haven’t read the whole article but I thought that it Had some relevance to us. I seem to remember a PEM research study finding our guts leaked on exertion, i don’t know if it was ever replicated. In the obese The theory is the bacteria or fragments that leak trigger an immune response.

wdb · Mar 11, 2020

The article was pay-walled for me but I found this one on the same topic

"Our findings suggest that in people suffering from severe obesity, bacteria or fragments of bacteria are associated with the development of type 2 diabetes," said the lead author, André Marette, professor at Université Laval's Faculty of Medicine and researcher at the IUCPQ research centre...

"We know that the intestinal barrier is more permeable in obese patients," said Professor Marette. "Our hypothesis is that living bacteria and bacterial fragments cross this barrier and set off an inflammatory process that ultimately prevents insulin from doing its job, which is to regulate blood glucose levels by acting on metabolic tissues."
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https://www.eurekalert.org/pub_releases/2020-03/ul-bpi030620.php

I believe this is the paper published
https://www.nature.com/articles/s42255-020-0178-9

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Type 2 diabetes influences bacterial tissue compartmentalisation in human obesity, 2020, Anhe et al

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