Review Type I interferons and endoplasmic reticulum stress in health and disease, 2020, Sprooten and Garg

Discussion in 'Other health news and research' started by SNT Gatchaman, Sep 30, 2024.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

    Messages:
    6,396
    Location:
    Aotearoa New Zealand
    Type I interferons and endoplasmic reticulum stress in health and disease
    Sprooten; Garg

    Type I interferons (IFNs) comprise of pro-inflammatory cytokines created, as well as sensed, by all nucleated cells with the main objective of blocking pathogens-driven infections. Owing to this broad range of influence, type I IFNs also exhibit critical functions in many sterile inflammatory diseases and immunopathologies, especially those associated with endoplasmic reticulum (ER) stress-driven signaling pathways. Indeed, over the years accumulating evidence has indicated that the presence of ER stress can influence the production, or sensing of, type I IFNs induced by perturbations like pattern recognition receptor (PRR) agonists, infections (bacterial, viral or parasitic) or autoimmunity.

    In this article we discuss the link between type I IFNs and ER stress in various diseased contexts. We describe how ER stress regulates type I IFNs production or sensing, or how type I IFNs may induce ER stress, in various circumstances like microbial infections, autoimmunity, diabetes, cancer and other ER stress-related contexts.

    Link | PDF (International Review of Cell and Molecular Biology)
     
    Sean, shak8 and Ash like this.

Share This Page