Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of [CFS] 2024 Wang et al

[In what is very likely a poor mice model of CFS]

Abstract

Chronic fatigue syndrome (CFS) is a long-term chronic condition that predisposes individuals to oxidative stress and disruption of the gut microbiota. In this study, sweet corn cob polysaccharide selenium nanoparticles (U-SCPSeNPs) with relatively small particle sizes were prepared using an ultrasound-assisted method. Transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FTIR), and ultraviolet-visible spectroscopy (UV-Vis) were used to characterize the U-SCPSeNPs and determine the monosaccharide composition of the U-SCPSeNPs. The U-SCPSeNPs were used to improve the CFS of the mice.

The results showed that the ultrasound-assisted method reduced the particle size of the SeNPs, and U-SCPSeNPs with a particle size of 76.74 nm and a selenium content of 186.83 ± 7.80 mg g−1 were obtained at an ultrasonication time of 40 min. Sweet corn cob (SCP) bound to the SeNPs through hydrogen bonding. In terms of energy production, the production capacity of Na+–K+-ATP, Mg2+-ATP, and Ca2+-ATP was enhanced by U-SCPSeSCP in CFS mice; In terms of oxidative stress, the levels of SOD and MDA were decreased and CAT and GSH-Px were increased by SCPSeSCP. U-SCPSeSCP improved the diversity and abundance of the gut microbiota in CFS mice, and decreasing the relative abundance of Firmicutes increased the relative abundance of Bacteroidota at the phylum level. This study provides a reference for synthesizing polysaccharide SeNPs and assessing the ability of U-SCPSeNPs to alleviate CFS.

Paywall, https://pubs.rsc.org/en/content/articlelanding/2025/fo/d4fo04195j

 

I have to admit: I did not have ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles on my bingo card.

 

I’m getting a bit worried that mouse cfs is suffering from a similar definition problem that human version was used for in the past

are they just asking labs to be on the look out for any lethargic looking specimen based on being in the 10% least active or hanging around hogging the mouse-hammock, yet seemingly also having sleep related symptoms?

or are these mice exhibiting phenomena like PEM after spending too long on the spinning wheel an equivalent set time period later? Can they tell if the mice have a similar tendency to want to lie flat etc?


Oh and I’m kinda struggling to tell what the special sweetcorn polysaccharide thing was for . I can half assume it was mashed because feeding whole sweetcorn to mice they theorise might have dodgy guts could be an ethical issue /they’d nibble it anyway … or is it that the processed version could be some sort of cure in humans that someone with me/cfs who eats a lot of sweetcorn snyway wouldn’t have noticed because it’s vastly different to that?