USA: NIH National Institutes of Health news

Marketplace: "NIH got $1.6 billion for research into long COVID. Where are the treatments?"

'Roughly 20 million people in the U.S. are now estimated to have long COVID, maybe more. And that initial $1.15 billion NIH got for the RECOVER program — which stands for Researching COVID to Enhance Recovery — has yielded few answers and zero approved treatments so far'

There’s good reason for the focus on observational research, according to Dr. Serena Spudich, a neurologist and researcher at Yale who’s working with the RECOVER program.

“There has to be a very, very strong urgency for finding treatments,” she said. “And at the same time, we will only find treatments if we understand the condition properly.'

'Dr. Ziyad Al-Aly, director of the Clinical Epidemiology Center and chief of the Research and Education Service at the VA St. Louis Health Care System, said his team and others did similar research earlier in the pandemic, “for peanuts, a few hundred thousand dollars that generated evidence much more robustly, faster, years ahead of RECOVER, for a small, small, small, small fraction of the funds.”

'At this point, more than four years in, “NIH should be laser-focused, laser-focused on finding treatment for long COVID,” he said.'

This fall, it held a kickoff meeting for the next phase of the RECOVER program, called RECOVER-TLC, which stands for Treating Long COVID. Now, Joseph Breen at the National Institute of Allergy and Infectious Diseases at NIH said it’s in the process of soliciting ideas for drugs and other treatments to trial.

“We have every intention of getting started as soon as possible,” he said. “In reality, we’re probably into next year.”

“The NIH can do this right, they have to do this right,” he said. “And they need to do it fast, which we know is possible.”

'Some legislators are already pushing for additional funding. Sen. Bernie Sanders, a Vermont Independent, along with several Democratic senators, introduced the Long COVID Research Moonshot Act in the Senate, and a companion bill has been introduced in the House. The Moonshot Act would provide $1 billion a year for 10 years for long COVID research. It has yet to be brought to the floor for a vote.'

 

Is there any chance It’ll be voted on before the change in government. While the Democrats have a senate majority?

 

As I understand it there isn't sufficient bipartisan support for it. So even if it were brought for a vote, the likelihood of passage is minimal at best. (Prove me wrong Congress!! I will celebrate if you prove me wrong.)

 

In my opinion, after Appropriations Committee (led by DEM leadership) cut LC funding out of the package in August (even with a letter from 17 Senate colleagues asking for LC funding to be included to Appropriations leadership), the LC Moonshot Act was DOA to me after that, even if D's got the trifecta in November (POTUS, Senate, House). There simply isn't enough support, from either side of the aisle, not just R's. Two LHHS leaders, Baldwin & Murray, two D leaders who in May had seemed like strong LC & ME advocates at the Senate LHHS FY NIH 25 Budget Hearing, had already essentially dropped their support by August (this is just my two cents, where I have collaboration with Baldwin's office and met with a clerk from the U.S. Senate Committee on Appropriations Subcommittee on Labor-HHS-Education).

The best case is a watered-down version somehow being absorbed into a larger bill (as someone else said on here), but even then I don't know the feasibility of that happening (I don't have enough policy experience to predict that).

 

Almost none. As in maybe 0.001%.

Senate majority means nothing, in the US senate legislation has to pass a 60% threshold and there's basically zero chance it does.

The only viable chance is a complete turnaround in 2 years, if Democrats regain a majority in both chambers, and somehow muscle through a provision in an omnibus budget like what happened with RECOVER. Which did happen in a Republican trifecta so it's not entirely impossible. Just about close to lottery odds.

 

I think there’s a loophole for budget bills (which this would probably be part of) where a 51 vote majority is needed instead.

There is near zero chances the democrats take back the senate before 2028. The 2026 map doesn’t allow the 4 flips needed without a crazy D+10ish environment. Though it’s very likely they will take the house back.

 

This is why a lot of us fought behind the scenes the last two (or three) omnibus bill cycles when D had control of Senate and the WH. We still couldn't get LC in that omnibus package with that dynamic. Many of us thought we could get it through. It was very telling, IMO. It's my personal opinion that we inflate D support (and I say this as someone who I'm sure you can tell I vote pretty liberally and have been pretty involved with Congressional advocacy over the last 7 years). It's just a different landscape in this current political climate.

 

10/29/24, Interdisciplinary Women’s Health Research Advancements: NIH and White House Women’s Health Workshop

"The goal of the initiative is to fundamentally change how we approach and fund women's health research. Particularly over the last two decades, we have made meaningful progress in studying the health of women and clearly uncovered data that are practical benefit to women now. However, despite the evolution of our research and important contemporary findings, as well as other important knowledge that has accrued over the years, oftentimes through clinical observation, there is still much more for all of us to do, not simply to catch up on health data for women due to historical underrepresentation of women in clinical studies and the need to study sex as a biological variable, but to fully realize the opportunity we have before us to address health conditions that affect women uniquely differently than men and or disproportionately, as well as commonly co-occurring disorders such as heart disease and depression and chronic conditions such as pain syndromes, Long COVID, all more common in women."

 

'Discovering Hope in Science is a podcast presented by the Office of Communications and Media Relations at the NIH Clinical Center'

Sept. 2023: 'Episode 1: Navigating COVID-19 Breakthrough Infections featuring Dr. Julio Arturo Huapaya (Johns Hopkins)"

"The current thinking is that there could be reservoirs of virus in the body that are not replicating but are still causing low levels of inflammation...However, whether this more sustained immune activation has a relationship to the symptoms of long COVID, it's still under investigation"

https://open.spotify.com/episode/1E91SRnMgJE5qcHtF8rRHv?si=a-xBd3mtQ-GTzIB6m7oTFg

NIH Clinical Center link on interview: https://www.cc.nih.gov/podcast/2023/episode-1

 

Vague, superficial, bland. I can't help but feel like Koroshetz is chiefly "making the right noises" while he awaits the progress of the NCCIH project unfolding under his supervision.

As long as he is funding and supporting the unit on "interoceptive disorders" he opened on his department, directed by Walitt (his second unit), where Long Covid and ME/CFS are "researched" as "as avoidant behaviour after an infection", and as long as he is supporting the NCCIH-initiated interoception project, then personally I do not consider Koroshetz a serious or safe person to lead any effort into Long Covid or ME research.

Link on some of Koroshetz' questionable activities "regarding the NCCIH's interoception project, its links to ME/CFS, and an incomplete list of worrying NIH developments here.

 

Maybe RFK will jettison Koroshetz & Walitt…

 

Wallitt is one of the more “alternative health friendly” people out there. I could see the opposite happening, him getting a promotion.

 

From the rumblings (the few contacts in HHS willing to share from inside those walls) I’m gathering I’d be very hard pressed for any promotions coming from NIAID-NHLBI-NINDS, but I hear you. For better or for worse (worse), he’s attached to NINDS. Of course we’ll see how it all shakes out since everything is conjecture until then.

 

“On The Hill: Next Tuesday, Nov. 19, at 10 AM ET, NIH Director Monica Bertagnolli, MD, will testify before the House Labor-HHS Appropriations Subcommittee. You can watch the testimony live HERE. No registration is required.”

Appropriations link: https://appropriations.house.gov/schedule/hearings/hearing-national-institutes-health-nih