Open USA: Randomized Double-Blind Placebo-Controlled Trial EValuating Baricitinib on PERSistent NEurologic and Cardiopulmonary Symptoms [LC] (REVERSE-LC)

REVERSE LC is a study to see if an FDA-approved drug called Baricitinib (ber-uh-sit-uh-nib), which is already used to treat COVID, can help improve thinking and memory problems and reduce fatigue for people who have Long COVID.

Who Can Participate?
Adults 18 and older who have had thinking and memory problems for at least 6 months after a COVID-19 infection

Screening and Enrollment
To make sure this is the right study for you, we’ll ask you to complete some questionnaires, take a few tests, and complete some bloodwork.
The questionnaires, tests, and bloodwork will be completed over 1-2 in-person visits to enroll into the study.

Study Participation
After confirming that this is the right study for you, we’ll send you home with study pills to take every day for 6 months. While you’re taking the study pills, you’ll be asked to come into your study site for bloodwork once a month for 6 months. At 1 month, 3 months, and 6 months you’ll also be asked to complete some questionnaires and tests during your visit.

After 6 months, you’ll stop taking the study pills. This doesn’t mean your time in the study is over though. For 6 more months, you’ll fill out monthly surveys in an app on your phone.

Finishing the Study
12 months after you start the study, you’ll be asked to come in for one last in-person study visit. At this visit you’ll do the same questionnaires, tests, and bloodwork that you did on your first visit.

Enrollment is limited to eligible people living in North America. Enrolling sites are limited by how much they are able to reimburse participants for travel costs. The study team at whichever enrolling site is most convenient for you will have more information.

Study sites

1. University of California San Francisco, San Francisco, California
2. University of Minnesota, Minneapolis, Minnesota
3. Vanderbilt University Medical Center, Nashville, Tennessee
4. Emory University, Atlanta, Georgia
5. University of Pennsylvania, Philadelphia, Pennsylvania
6. Yale University, New Haven, Connecticut

ReversingLongCOVID.org

ClinicalTrials.gov