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Vericiguat [drug for heart failure mentioned by Prof Schiebenbogen]

Discussion in 'Drug and supplement treatments' started by Hutan, Sep 27, 2022.

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  1. Hutan

    Hutan Moderator Staff Member

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    29,374
    Location:
    Aotearoa New Zealand
    Moved from the News from Germany thread.

    From the twitter thread above:

    About vericiguat, which does sound interesting:
     
    Last edited by a moderator: Oct 3, 2022
    Hutan, Sep 27, 2022
    #1
    sb4, SNT Gatchaman, janice and 9 others like this.
  2. FMMM1

    FMMM1 Senior Member (Voting Rights)

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    One for @Snow Leopard - from memory you are interested in the NO pathway, vasodilation.
     
    FMMM1, Sep 27, 2022
    #2
    Peter Trewhitt, Hutan and Snow Leopard like this.
  3. RedFox

    RedFox Senior Member (Voting Rights)

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    Location:
    Pennsylvania
    It's very fortunate that they've got funding to try some things. I think the idea of trialing medications that dilate blood vessels is rather odd, but I'm not up on the latest research on the cardiovascular system. If it's rigorous the data will speak for themselves.

    In that vein (hehe), is anything known about the design of these studies? These are the first trials in the program, so I'm guessing they'll be small, but will they at least be blinded?

    I really want to see research that creates answers, not more questions.
     
    RedFox, Sep 28, 2022
    #3
    bobbler, cfsandmore, janice and 3 others like this.
  4. FMMM1

    FMMM1 Senior Member (Voting Rights)

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    Yea trialling medicines is one way of understanding ME/CFS and potentially treating it. Sometimes there's an accidental finding (e.g. treating someone with ME/CFS with drugs for another disease) which suggests the drug might work --- not sure that applies in this case.

    Fluge and Mella (of rituximab trial) patented something relating to NO in ME/CFS - can't remember the details. So focus on NO isn't entirely new.
     
    FMMM1, Sep 28, 2022
    #4
    bobbler, cfsandmore, janice and 2 others like this.
  5. Sizzle

    Sizzle New Member

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    Sizzle, Dec 31, 2022
    #5
    Peter Trewhitt likes this.

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