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Vitamin D receptor is overexpressed in the duodenum of patients with irritable bowel syndrome, 2020, Miura et al

Discussion in ''Conditions related to ME/CFS' news and research' started by Andy, Aug 26, 2020.

  1. Andy

    Andy Committee Member

    Messages:
    23,010
    Location:
    Hampshire, UK
    Paywall, https://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.15225
    Sci hub, https://sci-hub.tw/10.1111/jgh.15225
     
    Andy, Aug 26, 2020
    #1
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  2. Midnattsol

    Midnattsol Moderator Staff Member

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    3,770
    They state that the relationship between VDR and Claudin-2 is controversal because it is decreased in the intestine of VDR knockouts but increased in the intestine of VDR knockouts exposed to dextran sodium sulfate? That's two very different states, one with an irritant to the epithelium and one without. Again in cell culture (and possibly rodents, I don't remember), many irritants/barrier disruptors can increase claudin-2 expression and this can be reduced by high levels vitamin D. So quite likely vitamin D have different regulatory action based on the environment.

    And no mention of tight junction protein organization, which may also be affected by vitamin D :( I agree with them we need more studies on how vitamin D can affect epithelial barrier integrity. Preferably also with measurements of vitamin D (I'd like measurements of the active form, although the inactive form is most common. The reason I want the active form is because studies on inflammatory bowel disease patients have shown that some of them have deficiency status of the inactive form, but still high/normal range of the active form).

    Edit: Effect of vitamin D on tight junction protein expression might also be affected by overall serum levels of vitamin D, so to be sufficient for the skeletal benefits at 30nmol/L may not be enough for these effects.
     
    Last edited: Aug 26, 2020
    Midnattsol, Aug 26, 2020
    #2
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  3. spinoza577

    spinoza577 Senior Member (Voting Rights)

    Messages:
    455
    I think this might be worth a thought:

    Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor.
    da Silva et al 2016

    from the abstract
    The ZnT10 transporter transports Mn and Zn out of the cytoplasma, i.e. out of the cell or into the golgi apparatus. A familiar form of PD has a defect here.

    It could mean several things, of course. Maybe there is now too less Zn and Mn in the cytoplasma, or its a counteract upon too much of it, or maybe upon too less VitD, or what else.
     
    spinoza577, Aug 26, 2020
    #3
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  4. Amw66

    Amw66 Senior Member (Voting Rights)

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    Would this also affect SODase synthesis and therefore antioxidant levels?
     
    Amw66, Aug 26, 2020
    #4
    spinoza577 likes this.
  5. spinoza577

    spinoza577 Senior Member (Voting Rights)

    Messages:
    455
    I have been told that nutrition would influence the amount of MnSOD, but I don´t know how good the evidence is. Very interesting, of course. I ever had thought though that this crucial enzym won´t undergo any significant changes under physiological circumstances.

    But I Know that in some cancers MnSOD is overexpressed (such has been shown several times) as part of the survival, but in others it seems to be the contrary, here though my reading hasn´t been that good, and I have no literature anyway, and it would be up to you.

    There has been one investigation on a plant, and here the authors said, that they have been surprised, that the level of MnSOD came out that independent from enviromental concentrations of this metal.


    Interesting could be this, about a blockade of the above mentioned gene:

    Epstein-Barr virus encoded EBNA-3 binds to vitamin D receptor and blocks activation of its target genes. Yenamandra et al 2010

    Elevated MnSOD has been found several times under acute EBV infection (5-fold rise in Semrau et al 1998), but not so for some other infections known for triggering CFS (same 1998). Ritter 1995 et al found autoantibodies against MnSOD in acute EBV infection.

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2191756/ 1995, including a link to 1998.
     
    spinoza577, Aug 26, 2020
    #5
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