Vulnerability factors for pediatric disorders of gut–brain interaction and implications for functional impairment 2025 Beinvogl et al

Andy

Andy

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Abstract​

Objectives​

To evaluate the frequency and number of vulnerability factors for the development of pain-predominant disorders of gut–brain interaction (p-DGBI) in a well-defined cohort of pediatric patients and examine associations with pain severity and functional impairment.

Methods​

Retrospective cross-sectional study of patients evaluated in a multidisciplinary abdominal pain program at a pediatric tertiary care center.

Results​

Two hundred and fifty-two patients were included, 70.6% female, mean age 13.6 ± 3.1 years; 37.3% had functional abdominal pain (FAP), 31.7% irritable bowel syndrome (IBS), and 31.0% functional dyspepsia (FD). At least one vulnerability was reported by 91.3%, with a mean of 2.2 ± 1.1 per patient, including early life events (42.9%), mental health problems (51.2%), a family history of mental health (52.4%), or chronic pain (55.2%) conditions. Functional disability scores were higher in patients with more vulnerability factors (p = 0.004). There was no association of increased number of vulnerability factors with pain intensity A triggering event precipitating p-DGBI symptoms was reported by 63.9% of patients: gastrointestinal infections (41.0%), extra-intestinal infections (16.1%), psychological stress (15.5%), concussion (8.7%), onset of organic disease (7.5%), medication reaction (5.0%), surgery (4.3%), or physical injury (3.7%).

Conclusions​

Results support the biopsychosocial model suggesting that patients with p-DGBI are inherently susceptible to developing chronic pain due to biologic vulnerabilities and environmental factors. While infections remain the most reported trigger of p-DGBI symptoms, this study newly identifies other triggers. The association of increased number of vulnerability factors with worse functioning raises the question if there may be a cumulative adverse effect of multiple vulnerability factors.

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The paper said:
Results support the biopsychosocial model suggesting that patients with p-DGBI are inherently susceptible to developing chronic pain due to biologic vulnerabilities and environmental factors. While infections remain the most reported trigger of p-DGBI symptoms, this study newly identifies other triggers. The association of increased number of vulnerability factors with worse functioning raises the question if there may be a cumulative adverse effect of multiple vulnerability factors.
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Really Dr Magooing it on turbo here. You especially have to love how they decided on those "vulnerability factors", then somehow, unexpectedly, found them. Even though it actually invalidates their entire premise, with the vast majority of those triggers being purely biomedical, while illness can easily be mistaken for "stress" anyway.

This is all really following the exact same process as reactionary politics: the bigger the lie, the more suckers you loop into them, the harder it is to move away from them, because it's far too embarrassing to admit to having been so easily duped. I genuinely expect that a lot more people who ended up drinking toilet water leaking down a statue will have better insight into having been taken for suckers.

Because here it's the people who rigged the statue to leak toilet water who ended up scarfing it down the most.
 
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