When cells go boom: Study reveals inflammation-causing gene carried by millions

"This is a good thing in the case of a viral infection, where necroptosis not only kills the infected cells but instructs the immune system to respond, clean things up, and start a more specific, long lived immune response," Dr. Garnish said.

"But when necroptosis is uncontrolled or excessive, the inflammatory response can actually trigger disease."

https://medicalxpress.com/news/2023-10-cells-boom-reveals-inflammation-causing-gene.html

The paper is at

A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation

https://www.nature.com/articles/s41467-023-41724-6