Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease

"This review provides a brief history of how our knowledge of endothelial function has advanced and now recognize that the endothelium produces a plethora of signaling molecules possessing paracrine, autocrine, and, arguably, systemic hormone functions. In addition, the endothelium is a therapeutic target for the anti-diabetic drugs metformin, glucagon-like peptide I (GLP-1) receptor agonists, and inhibitors of the sodium–glucose cotransporter 2 (SGLT2) that offset the vascular disease associated with diabetes."

https://cdnsciencepub.com/doi/10.1139/cjpp-2019-0677