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  1. Sean

    Neurodevelopment Genes Encoding Olduvai Domains Link Myalgic Encephalomyelitis to Neuropsychiatric Disorders, 2025, Lidbury et al

    Frank Zappa's take on it was: Without deviation from the norm there is no progress.
  2. Sean

    DWP assessor reveals 'sneaky' tricks used in PIP exam such as chair choice test

    Chairs with arms can be a problem for me as I discovered years ago that I can relieve back pain to some degree when sitting by keeping my arms folded across my chest (it helps lock the back into a relatively comfortable position, reducing the amount of active effort required to keep it there)...
  3. Sean

    WGS (whole genome sequencing) findings possibly linked to mitochondrial/metabolic dysfunction – anyone with similar results?

    And some, like me, who can get both effects (though not at the same time, it is either one or the other). Unsurprisingly the amount, but also the type of drink consumed, are also big factors, for me. When people say 'alcohol', in this context that needs to be defined precisely. Do they mean...
  4. Sean

    Neurodevelopment Genes Encoding Olduvai Domains Link Myalgic Encephalomyelitis to Neuropsychiatric Disorders, 2025, Lidbury et al

    Could be measuring the ability and/or willingness to mimic or conform to normative models of 'smartness'.
  5. Sean

    Thirty Minutes to Transform Care: A Mixed-Methods Study on Brief Psychosomatic Education for Unexplained Symptoms 2025 Sioni et al

    Okay, so they showed that clinicians can be more effectively trained to rote learn the unproven hypothetical model. And the benefit to patients of that is...? role-play illustrating empathic validation techniques Yeah, that's how empathy works and is learned. :rolleyes:
  6. Sean

    No Evidence for Unconscious Attentional Bias in People With Clinically Significant Symptoms of Functional Gastrointestinal Disorders:... 2025 Ejova+

    I wonder if the subjects (patients and controls) all being psychology students was a significant uncontrolled variable?
  7. Sean

    Chronicity rhetoric in health and welfare systems inhibits patient recovery: a qualitative, ethnographic study of fibromyalgia care, 2025, Cupit

    ...with a meta-analysis from 14 RCTs of telerehabilitation demonstrating statistically significant improvements... But not clinically significant? And on what outcome measures?
  8. Sean

    Unwilling or unable? Interpreting effort task performance in myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Kirvin-Quamme et al

    Nice work, authors. Thanks. :thumbup: I do like brevity. :) Also, good you got in a mention of inadequate statistical power. That is an important limitation of the Walitt paper. Thank you. It is a disgrace that patients have to do the medical profession's dirty work for it, and all too...
  9. Sean

    Preprint A Proposed Mechanism for ME/CFS Invoking Macrophage Fc-gamma-RI and Interferon Gamma, 2025, Edwards, Cambridge and Cliff

    IIRC, it is more than one person, and the name is just a nom de plume.
  10. Sean

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    No. These guys are some of the best propagandists and political manipulators in the business. How else have they managed to hang on for so long, with so little evidence? That was no accident.
  11. Sean

    Patients with severe ME/CFS need hope and expert multidisciplinary care, 2025, Miller et al

    I agree it isn't just for AI. They are just generally flooding the whole zone with whatever shit they can. Influencing AI is just a new part of the zone these days, along with social media. Pretty sure they have the ongoing update process for the Australian Guidelines firmly in their sights...
  12. Sean

    UK House of Lords/ House of Commons Questions

    You might need to explain the joke to those unfamiliar with musical notation. (Assuming it is supposed to be a joke.)
  13. Sean

    UK House of Lords/ House of Commons Questions

    @Tao Fogger Love your avatar. :emoji_grin:
  14. Sean

    The Impact of Definitions of Disease on Overdiagnosis, 2025, Tikkinen/Halme/Guyatt/Glasziou

    They are not going to be able to arbitrarily re-define their way out of the deep slippery hole they have spent decades on furiously digging themselves into.
  15. Sean

    Psychology Today: In Search of a Coherent Understanding of ME/CFS and Long Covid, Jake Hollis

    I am not going to waste my time reading yet another piece of recycled crap. But I will bet he did not address the matter of adequately distinguishing correlation v. causation, of cause v. consequence. Once again this horseshit tells us far more about what is going on in the author's psyche than...
  16. Sean

    I'm able to exercise but am still disabled

    Anybody who thinks a tiny amount of a chemical cannot have much effect on your mind and body should try 25 micrograms of pure LSD and a tenth of a microgram of lovely fresh warm polonium 210.
  17. Sean

    The Implications and Predictability of Sleep Reversal for People with [ME/CFS]: A Machine Learning Approach, 2025, Dietrich, Jason et al

    One of the very few useful management tools for me is not having to adhere to a fixed sleep cycle. Contrary to the psycho-behavioural view of 'sleep hygiene', being able to rest/nap/sleep whenever I need to is pretty helpful – indeed necessary. My sleep pattern is fairly stable now days and of...
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