Search results

I might have misunderstood, but the article is a bit difficult to follow for me: first it suggests that one should measure not only the presence but also the severity of symptoms and then it argues that a reduction in functioning should not be required in case definitions. I would argue that...

'A pre-determined reduction in functioning should not be required to have long Covid' I disagree with this and think it is one of the big problems with Long Covid case definitions in research: they selected people with symptoms that had relatively little impact on their functioning. What is of...

This is what I got for the GEE modelling with the 3-way interaction: model_formula = "Successful_Completion_Yes_is_1 ~ Sex_Male_is_1 + Value_of_Reward + Probability_of_Reward + Trial + Expected_Value + is_patient + Trial * Trial_Difficulty_Hard_is_1 * is_patient" Taking the results for the...

My initial guess would be to ask for 2016 anyway: if it is too large, perhaps we could filter it ourselves but then at least we have the info. But I don't have any experience with these things so happy to hear what others think.

Thanks for pointing this out and apologies for the typo about the p-value (I accidentally wrote 0.41 instead of 0.041). So when taking al trials into consideration in the GEE modelling, the results are quite similar so I don't suspect anything fishy here. I'm still not quite sure what they have...

I also don't see missing data, HVA has data for all trials in my dataset. Perhaps an error with uploading or something like that?

No problem, I think it is very useful to have more people like you with a statistical background on the forum. I hope you will stick around!

Yes, I could try to help a bit (depending on how much info they send and how feasible it is to go through it).

I don't have any plans but believe that @andrewkq and @EndME are working on a letter. Thanks. It would be great if could someone with stat expertise could look at the GEE modelling as I had some troubling replicating their findings. I don't have any statistical training so it is possible that...

They write: "The ICD-10 diagnosis code for ME/CFS (G93.3) belongs to the 'General Signs and Symptoms' cluster". Hard to make sene of this paper if you don't how they made those clusters of diagnoses. Info about the system they used, The Adjusted Clinical Groups© case-mix system from Johns...

That's great to hear. I don't think there is a strict time limit here so please take your time. An acknowledgement like the one you suggest would be great also for other S4ME members who contributed but may not be able to sign. Most of the arguments were already made by others forum members, I...

I've been trying to calculate this by adding a new column: 'previous_trials_completion_average'. It initiates at value 0.5 (equal chance of completion or not) and then for row i takes the average of the completion rate of the previous (i-1 rows). It calculates these means from the...

Thanks for the interseting comparison @Murph Do you mean in the field of ME/CFS or in general? That would be great. A (likely stupid) question from someone with no experience with metabolomics: I noticed that you plotted 'level in cases divided by level in controls': would it make sense to...

Some more data on the correlation between hard task choices and successful completion rates. I found a value of r= 0.12, that is not significant with this sample size. Patient D, H and A constitute the 3 dots at the bottom of the graph with low successful completion rates and a large...

Great news! I unfortunately (due to personal circumstances) will not be able to sign or co-sign a letter as I prefer to remain anonymous. So I hope that you, Andrew and others can take this further. Feel free to use or change anything from the draft above (I'm also happy to help out with further...

Unfortunately, I have not been able to replicate their statistical models. This estimation came from @andrewkq in this post: https://www.s4me.info/threads/use-of-eefrt-in-the-nih-study-deep-phenotyping-of-pi-me-cfs-2024-walitt-et-al.37463/page-16#post-519455 I used data shared by @Karen Kirke...

I don't know if this thread has just slowed down or if others are working on a letter behind the scenes. I think a lot of valid points were raised that prove that Walitt et al.'s interpretation of the EEfRT data is seriously flawed. I have written a first draft for a letter to be sent to the...

This is their section on CFS: Chronic fatigue Chronic fatigue syndrome is characterized by an overwhelming sense of tiredness, lack of energy, and persistent and prolonged exhaustion, even after rest119. This syndrome is associated with systemic immune activation and has been frequently...

Abstract Celiac disease (CeD) is a chronic immune-mediated condition triggered by gluten consumption in genetically predisposed individuals. Approximately 1% of the general population is affected by the disorder. Disease presentation is heterogeneous, and despite growing awareness among...