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Here are some quotes I found about the need to calibrate the effort and the possibility of participants using strategies. I think EndME and Bobbler already posted the most important ones. Boldings are mine. Calibration An important requirement for the EEfRT is that it measure individual...

I also had a look at some of the trials posted by EndME. The proportion choosing hard tasks seems to be quite low in the Walitt trial but it is difficult to compare because of changes to the test procedure. The completion rate does seem to be above 90%, only the autism cohort scored a bit...

I also had a go at the data posted by Evergreen. I’ve ignored the 4 test trials and the invalid data by HV F. The figures below only show the raw data, not modelled data controlled for factors such as sex and number of trials per participant. Feel free to point out errors (I hope I didn’t make...

No I haven't tried to as I was looking for the EEfRT data. Were you able to replicate their GEE results? If so, would it be possible for you to share your code (this might help in better understanding the results).

Has anyone found the R code that they used to analyse the results of the EEfRT? The paper says that the code is available here but I couldn't find the part where they analyse EEfRT data...

So mysterious while it is probably just fatigue/illness that caused the difference. If I understand correctly, Walitt and colleagues discount fatigue as an explanation because the choice for a hard task declined at the same rate in the patient and control group (figure 3A). But that means they...

They give this overview in the article but I don't think the evidence for these 'biomarkers' is convincing enough to call them a biomarker for ME/CFS or Long Covid.

Quote from the paper: "The three main factors contributing to suicidal thoughts were (i) being told the disease was only psychosomatic (89.5%), (ii) being at the end of one's strength (80.7%) and (iii) not feeling being understood by others (80.7%)."

So the main conclusion is that the ME/CFS patient population is heterogenous but that without many differences between the cohorts at different clinics. Or as they write: "This suggests that expert clinicians are recognizing the same clinical entity, albeit one that is far from homogeneous."...

Looks like an excellent response.

They basically found nothing that stood out which isn't very surprising giving the very low sample size and the fact that ME/CFS is probably a heterogeneous syndrome with multiple causes. Most of the attention in the paper goes to the 'alteration of effort perception' hypothesis which...

So they took the prevalence estimate of 1.5% from the CDC pulse survey and the disability weight of 0.21 from the Global Burden of Disease (GBD) Long COVID Study Group. Don't think the latter study has been published yet? Yes, they did not take Years Lost due to Death (YLL) in take account...

Speakers include Unger, Systrom, Bateman, Ed Yong, Lacerda, Bergquist, Hanson, and Scheibenbogen amongst others.

They should just report the effect size, which will likely be around than 0.15 standard deviations which is very small. Hard to take this seriously in a trial that did not control for attention, expectations etc.

Just noticed that in their discussion section they try to justify their interpretation as follows: "Research completed since we started this study suggests a minimally important difference of 0.04 on the PROPr score between groups. Our observed differences of 0.03 (95% confidence interval 0.01...

The difference for the primary outcome was 0.03 on the PROPr questionnaire which apparently has a scale from -0.22 to 1. Table 2 shows that the standard deviation is somewhere around 0.18 so the effect size is approximately 0.16 of the standard deviation, which is very, very small. "A...

As far as I can see Mitochondrial oxidative phosphorylation (OXPHOS) capacity was not significantly different in the 15 ME/CFS patients compared to controls (figure 1). The interesting part of this study is that they took muscle biopsies but I don't really understand the results. Anyone who can...

There was an earlier trial where they tested live and telephone CBSM for ME/CFS. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270375/