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The largest difference was found for miR-448 which had not been tested in ME/CFS before but it was found to be increased in various auto-immune diseases (the article mentions RA, SLE, SS, UC). Might be something to look out for in other studies.

They also looked for abnormal values of NK cytotoxicity in subgroups such as patients with severe ME/CFS or sudden onset ME/CFS but found nothing. There was also no significant correlation between NK cytotoxicity and symptom questionnaires such as subscale scores of SF-36, MFI-20, CDC-SI and PROMIS.

The paper states: "Participants reporting an infection at onset were more likely to have had ME/CFS symptoms for over 10y than those reporting no infection at onset (66.8% [n=7,246] vs. 45.1% [n=1,183]). This is despite their similar ages (medians 54y [IQR=43y–64y] and 52y [IQR=41y–62y]...

The 2004 study is a review of several small studies done in the 1990s. I wonder if the technique is still relevant today and if it would be worth repeating it today with a larger sample size. I would suggest an exercise test that is more focussed on muscle endurance rather than a short burst of...

Michelle James (Stanford) just said they were doing TSPO-PET/MRI imaging of the whole body, not just the brain, and found increased signals in muscle of (female but not male) ME/CFS patients compared to controls. Small sample size though, I think only 6 pairs. They are also look into GPR84 as a...

Thanks for highlighting this. If I understand correctly the main results highlight the percentage of participants that had an alleviation for each of the 14 PASC symptoms while the supplementary table Zeynep highlights simply gives the number of participants that still reports each of the 14...

Did you manage to do the analysis you planned? Quite impressive what you are doing by the way, hope it shows some interesting results. In my personal case, the most demanding cognitive efforts would be reading complicated texts like scientific papers and I think that would be difficult to see...

Had the impression that most researchers talked about past research that was already published, not about what they are working on now or what is in the pipeline.

Thanks

Does anyone know which 4 questions are in the DSQ-Brief?

It seems that patients ate worse (more unhealthy) but that did stop the authors from claiming the diet intervention was equally a success. "the overall diet quality level did not improve on average (ΔM=−10.30, SD=20.84) because participants tended to consume less whole-wheats products...

Don't say: "The intervention failed to improve outcomes compared to the control group." Say: "The interventions were equally effective!"

Quotes from the article: "In this randomized crossover trial, we used the biopsychosocial model to design tailored lifestyle advice named PROfeel. Realizing that treatments by specialized healthcare providers such as CBT have long wait lists, we decided to implement the advice as a...

It is kinda of strange that the true prevalence studies found low prevalence rates (0.2-0.4%) where the majority of patients (80-90%) are undiagnosed and that these surveys find that 1.4% of the population says they have been diagnosed with CFS. That is quite a large mismatch. if I were to...

Looks like an interesting paper with a large sample size. Unfortunate that it is only published in German and behind a paywall.

Suspect the data might not be very reliable but still found this notable: The percentage of ME/CFS increased with increasing rurality, from 1.0% and 1.1% in large central and large fringe metro areas, respectively, to 1.5% in medium and small metropolitan areas and 1.9% in nonmetropolitan...

Thanks @Hutan

They write: We developed an objective performance single value, the Functional Limitation Index (FLI), calculated as (VO2 peak/VO2 SM)/(VO2 SM/VO2 predicted). I'm not sure what VO2 SM but I think it is VO2 Supramaximal, the VO2 measured at full exhaustion of the patient at the very end of the...

I don't think infectious retrovirus will become one of the focal points and trends in future CFS research. They probably picked up the XMRV papers as these were published in prestigious journals and did not bother to read them or see how the story ended.

I think it depends on the goal. When there is extensive testing with multiple visits that is quite taxing it might be most appropriate to compensate patients for their efforts. In other cases, when participation is less taxing but you need as many participants as possible, for example for...