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Sorry I've just been through exam season and my mental fatigue is adding up. When you are talking about folding and reducing environments, do you mean how it affects disulfide bridges in the protein? A lack of reduced glutathione > oxidized cysteines and formation of disulfide bonds? I'm not...

I'm not sure level of activity changes how a protein will be affected by free radicals. Fatty acids (unsaturated ones are most prone to this) are not enzymatically active for example, but can still be oxidized, because of their chemical properties. Mitochondrial membranes could be affected...

But oxidative stress would surely affect other proteins as well as the mitochondrial ones? It does not discriminate.

I have met a student of Wyller and been told about the aggressive ME patients community. Ah yes, I'm sorry I can read the research too :rolleyes:

Thanks for the heads up @Kalliope, I don't think I will listen to the program now. How is it possible to mess things up like this :banghead:

In my studies it's been used in cell biology and biochemistry mostly, and somewhat in microbiology. Stress in this case means a type of pressure, but it's not measured in mmHg. It's more along the lines of stressing a system with too much heat, cold, poor nutrient medium (but unlike a cell...

Which could be caused by the high oxidative stress, the system becomes overloaded. Low glutathione (our strongest antioxidant) is also not uncommon in diseases, it gets used up at a higher rate than normal. This is why I wish dieticians would be more involved with the chronically ill, our bodies...

I do believe oxidative stesss is a problem for us, but so is it in many other diseases as well. That overexercising can induce flares in autoimmune diseases is not uncommon. Some years ago there were someone who looked at oxidative stress and heat shock proteins (HSP) in CFS patients (I think...

I remember happily exclaiming to my bf "And they even looked at the urine!" :D Mine smells fruity from time to time and can be cloudy, but that happens also when I'm not in PEM. My sweat smellls differently when in PEM. Like others I pee more often when in PEM and feel dehydrated no matter what...

This looks like a paper I will enjoy reading when I get the time :)

Good thinking om fatigue as a problem for many people, weird conclusion about ME.

Also heat-shock proteins that help cells when they are stressed (for one reason or other). Why hasn't anyone followed up on that? I'd also like more studies on our blood vessels and nitrogen oxide.. And perhaps even nitrogen oxide and the electron transport chain.. I like this as it is...

I don't read much about turmeric, but other compounds that's not very well absorbed can still be anti-inflammatory from acting on gut wall integrity, microbiome, or something else in the gut that could lower inflammation in the body. Quercetin for instance can change protein expression (and...

It is a redox change, lactate is the reduced form of pyruvate. To do this, cells use NADH as a reducing agent. To keep up with energy demands, cells import glucose, pyruvate gets turned into lactate and then transported to the liver to make more glucose. Why would there be so much pyruvate be...

Interesting.

Remember glutamate in itself is not bad, it's when the body cannot regulate it property it becomes problematic. And when that happens it can increase oxidative stress which in itself can lesd to dysregulation of this system. That's one viscious circle. How about glutathione regulation? It is...

Glutamate is the anion form of glutamic acid, while glutamine is glutamic acid + and extra NH3 group. They can be synthesized from eachother. Excess glutamate is common in many chronic health conditions (also together with reduced glutathione). A decrease in glutamine is often seen together...

Bioinformatics AND microbiome? :woot: Wish I were done with my master degree.

This. A hundred times this.

Haven't read the study properly, but the abstract says something like this (not sure if I managed the "simple", though): Basicly they looked at methylation at certain CpG islands found in the promoter area of TRPA1. They found that an increase in methylation at CpG -628 and -411 led to a higher...