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Excessive physical training > (low grade inflammation >) excessive oxidative stress > change in dopamine and glutamate in the brain > cognitive fatigue and more impulse behavior (I'm simplifying a bit).

BBC Radio crime allows for online listening of shows that are currently running. Right now they have a Paul Temple play, I also enjoy their versions of Hercule Poirot and Mrs Marple when they show up, and also the two Cordelia Gray plays (they could be found on youtube not too long ago), and...

Andy is correct :) It is a very potent toxin that the immune system reacts strongly to. This could explain the flu like feeling after overexertion. Or part of it, for some people. There are many things that affects this. Exercise increase LPS translocation also in healthy people, and normally...

Overtraining/exertion and the gut has been linked to ME/CFS previously with the increased translocation of LPS from the gut to the blood, and bacteremia. It is very interesting. I wonder if increasing gut barrier integrity before exertion could decrease symptom burden and/or PEM.

A better translation of the headline would be "It's those who are severely ill who suffer, not the healthy ones" :)

That some people promoting probiotics and gluten free foods don't know what they are talking about (a lot of the gluten free food you can buy has poor nutrient density, so even if that person had a problem with gluten they are just exchanging that for poor nutrient status which is of little/no...

If it's cause or effect I still want to do something about it. Exercise has been found to increase intestinal permeability, more so in pwME. Increased bacterial translocation (and food antigens) then causes inflammation and can give that "flu like" feeling. Also with impaired gut barrier...

This. Zonulin has also been implicated in loss of blood brain barrier integrity.

I do hope this idea is implemented, and not just in psych research. Another thing is creating an environment where admitting to being wrong is not met with some sort of humiliation/harassment/some other conseqeunce people will do alot to avoid. Rather it's an opportunity to better understand a...

I like this idea of thinking. I don't feel like I have a baseline level of activity, it changes a lot. The ceiling does too of course, but as you say the implications are different. I can be below a ceiling a function more or less ok.

As Long as it holds some legitimacy there might be better methods used to research microbiome related questions later on. Too bad both psychs and dieticians don't have a lot of cell biology or bioinformatic experience, I think those fields would be helpful (especially since a lot of both psych...

Hormones aren't neglected by all who study the gut-brain axis though. And in my opinion, even if it sometimes can be far-fetced and overreaching, it is much needed to get some new ideas into psychology. There are some interesting findings and connections out there.

This. Banning one chemical when another much like it is just used in its stead because no research shows the replacement is bad (like BPA and BPS) and then waiting for research to catch up and then do another change.. it's frustrating to say the least.

I'm not too fond of ketogenic diets (maybe because my body can't cope with them very vell :p I do believe they work better for males and not so well for females, although there are females that report to thrive on this kind of diet and males that do not). I also believe the positive effects of...

There's more than one procedure done at the hospital that can alter metabolomics-data, not just autoclaving. And I wonder too how often it is not properly handled when analysing the data, although it is not always easy to see, so I guess you can only do your best. I'm also a fan of volcano...

But like they write themselves, blood is not a good place to do transcriptomics (or, I guess it depends what one looks for, I would be more interested in muscle or gut tissue personally, but that's way more invasive).

A diverse microflora is considered good, but a supplement does not need to have many species. I usually eat fermented foods, but to reduce the amount of food prep and cooking the last few weeks I've been testing a supplement with four strains. Quality over quantity :) What bothers me a bit is...

There might be correlations between "leaky gut" and a more leaky blood-brain-barrier, that could perhaps cause brain-fog?

I want transcriptome data from the gut of patients in PEM, to look at proteins involved with instestinal barrier function. It's not just bacteria that can affect this. And from my own experience when I've been very ill and had other cook for me (if I managed to eat) the diet has not always been...

Sounds plausible to me. Increased NO could be positive due to the vasodilation effects, but NO is also an inhibitor of energy production..