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Fits well with that metabolomics dataset that showed reduce vitamin E metabolites or something? Vitamin E is important for protecting cell membranen from oxidative damage. Not to say that ME patients have a diet deficient in vitamin E, but we might have increased need for that and some other...

It says something about it here: https://link.springer.com/article/10.1007/s00217-016-2772-3 "Consumption of meals induces increase in cortisol level. This response is strongly marked in men than in women. Influence of kind of macronutrients in taken food on cortisol concentration was...

I don't always get very hungry when I have PEM, but often. To me it makes sense, if the body has an increased need for certain nutrients (and energy) then starting up some hunger-signalling pathways seems like a good idea.

But since people experience PEM at different times after exertion, you would probably have people at different stages of PEM if you had blood collections at specific time points.

I was recommended any of these three by a researcher at my university (he works with translational neuroscience): Eric R. Kandel – Principles of neural science Dale Purves – Neuroscience Larry Swanson – Brain architecture: understanding the basic plan He said Purves was the most accessible one...

I haven't read the whole thread @Wonko, but I definitely plan to. I'm working the same angle, mostly with foods (high nitrate foods, antioxidants, vitamin E, omega3, electrolytes). I'm also testing red light therapy at the moment. I see you're testing out ketosis, I've never had any luck doing...

I don't see how the pro BPS people have a "broader perspective", they do repeat themselves again and again, they don't seem to value input from either patiens or biomedical research. That, to me, seems more like a closed mindset. And wording it like it's "pure biomed" vs "broader perspectives"...

That depends what the body uses it for ;) It can regulate different things in the body. In this case it mentions how it can induce a pro-inflammatory state, which would be useful depending if you need the immune system acting up. It's a vasodilator, so it can increase bloodflow to tissues...

Interesting. There was one exertion study on CFS-patients where they measured high levels of NO metabolites, although I can't remember seeing this repeated in other studies. From: https://www.liebertpub.com/doi/10.1089/jwh.2008.1255#B7 Couldn't find it at scihub unfortunately. Also I have no...