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Hi @Justy, I too have experienced pseudobulbar affect, though not quite to the same degree of severity as what you've described. One of the old school books or articles I read on ME described it as being part of the clinical picture during the initial stages of the illness. I forget who said it...

I seem to recall filling out their questionnaire. Useful study. My ED encounters (for what were OI flares in hindsight) have been uniformly negative, encountering people who ranged from criminally stupid or lazy to smart and compassionate but having no knowledge whatsoever of dysautonomia. It's...

I've had concerns about this line of research (on the other forum) since the MRC funding was announced for this project. Academic psychiatrists have been asserting for 20+ years that interferon-alpha treatment for hep C is a biological model of depression. There are 1000s of publications on this...

A recent low carb study engaged in outcome switching to obtain the desired result. https://www.biorxiv.org/content/early/2018/11/28/476655

I knew those endless hours of studying Latin declensions in junior high would finally pay off in a big way one day.

My onset was similar. From what I can tell, the current position of the medical industry is one of aggressive denial about the sometimes devastating and permanent alterations of the microbiome caused by (often needlessly) prescribed antibiotics, especially when given in infancy before a robust...

This would be in line with anecdotal observations discussed on other fora that massage makes many patients worse. I don't know that it's actual PEM he's measuring but it's interesting nonetheless that something this innocuous elicits symptoms and biological alterations.

I don't think this study should be dismissed out of hand just because of the author's BPS allegiances. Although this is not an ME/CFS study per se (since he did not measure PEM), it still tells us something interesting about the relationship between early immune activation and persistent fatigue...

I've read Hyde's book. It's full of bombastic claims and zero supporting evidence (evidence meaning replicated peer-reviewed research).

Well it’s easy to change the results by for instance taking medications. Hyde’s buddy Goldstein observed decades ago that sending patients for a SPECT scan was of no use to him anymore since a drug he gave them could change the pattern of brain activation within seconds and in the opposite...

There is a reason no one uses SPECT scans anymore.

He publishes nothing because there is nothing whatsoever there to report.

So, this talk was more interesting than I anticipated given Pariante's egregious past statement that ME/CFS is caused by 'excessive rest'. It appears that the subset of people who develop persistent fatigue following IFN alpha have a significantly higher IL-6 and IL-10 response to treatment...

It might even work in our favour if the same abnormality is shown in a 'real' disease like MS or lupus. Harder to deny that way. If a novel, unfamiliar test shows an abnormality only in ME/CFS, the BPS crowd will still be able to play god of the gaps strategy and say it's caused by spending too...

I think the purpose of research is to get the silent majority of doctors, especially the younger generation, to accept that this is real, people who may not have strongly held BPS views or may not even know what ME/CFS is. Obviously the BPS lobby will never accept any amount or quality of...

Looking at some recent reviews of 100 year old psychiatric literature, it appears that fever therapy (pyrotherapy) by intentionally infecting the patient with malaria was quite effective for neurosyphilis (this was in the pre-antibiotic era). About a quarter of psychotic patients were able to...

I think he said some might have elevated serotonin and others low depending on receptor adaptations that would take place.

I love how academic psychiatry keeps rediscovering things (like fever) that every asylum shrink knew 100 years ago.

There have been some previous metabolomic studies of MDD and other conditions labelled psychiatric but you know how it goes, everyone measures different things. There are a lot of metabolites.

This study measured plasma metabolites. What's going on in the brain is anyone's guess until we see some CSF data.