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Why's it always Chinese teams doing Mendelian randomisations? Did they just rediscover the technique? Mendelian randomisation must be okay right? It must be a legitimate technique? I am always suspicious because the very first one I read tested a link from long covid to mecfs and found none...

I agree the comparison is not apples with apples. Many differences. For further reference, the SF-36 from the unblinded phase 2 rituximab trial. means rose from ~40 to ~60 at 10 months. with very high dispersion. And this is the 2011 phase 1 trial. A bit hard to interpret but I think we're...

For comparison, some data from the placebo controlled rituximab trial. The Daratumuma sf-36 data ( from 25 to 55) look quite good compared to Rituximab (the centre chart below shows those getting the drug going from 35 to ~43 by 9 months) . Also in ritux the number of steps taken rose from...

Chris says in this video that he and Rob Phair will publish on the itaconate shunt later this year. Which will be interesting. Sounded more like hypothesis and explication of how it might work than big data, but perhaps I'm misreading that. He seems to be advancing the idea that if we are...

Sodium bicarbonate update! I think it is always worth documenting when you make a big mistake. here's my most recent. Last night I took way way more sodium bicarbonate than usual. several grams. maybe even 10g. this morning I have a migraine, which I've never had before. nausea and pain...

I should report my null results: didn't feel any different after trying bicarb soda. that's just once though. Will try again. I should also report my other reason for wanting to try this instead of a b-complex:: I had some blood tests and my b12 levels were too high, probably from taking this b...

I started taking some fizzy b-vitamins a while ago. I perceive a benefit over a short-tun time horizon, perhaps 1-4 hours. I've recently tried to be a lot more skeptical about what it is in any product that might be delivering the benefit. I had a good look at what they put in these tablets...

The things we know genes do map to diseases that have funding. Every gene with a study on it is an oncogene because cancer funding is wide and deep like the Pacific ocean! And as @jnmaciuch points out, every other gene appears to be a brain gene, because neurology has done a lot of work too.

I've been varying my diet recently. I find sugar has wonderful short run effects, I think it changes some things for the better, not just readily available energy but also maybe blood pressure. However periods I can manage to cut it out are periods where my PEM is far less. Sugar is a real...

This is great. Do I have a guess what "flux" will be? Na.

Another new paper with a lot of features that seem relevant to Hwang's finding: UPR, Tudca, extracellular matrix, fibronectin: Integrin-Specific Signaling Drives ER Stress-Dependent Atherogenic Endothelial Activation An interesting finding is that disturbed turbulent blood flow creates...

I think the Lumia device that they have started marketing to people with POTS in the US is a chance of giving this data in a really useful format. it measures blood flow to the ear, which is (they argue and have data to show) a good proxy for blood flow to the brain. Now, this proxy relationship...

I"m excited that Hwang has his eye on ME/CFS all the time, even in papers on pre-existing research streams that needn't mention it. I feel we have him on our team now! I remember that in his big paper he found weird issues in PERK and eif2-alpha., which are activated by endoplasmic reticulum...

I used to be a patient there and I've done the test. Admittedly it was over 10 years ago (possibly I"m even in the research cohort being discussed!). I thought the nurse recorded a subjective score but it was given by me, I vaguely remember them asking me to rate my difficulty holding it...

This looks like really clean basic science, I like it, perhaps it causes an aha moment for another research group. I've never heard of ADAR before but certainly the antennae go up when we see adenosine and inosine mentioned.

The last couple of minutes were particularly interesting in my view. Daniel gave his best guess for a big picture explanation of ME/CFS, and he basically says that evidence suggests: immune cells (probably b-cells and cells derived from them) are over-reacting, perhaps because of a) a signal...

Doctor told me I had Raynaud's. It had come on suddenly. My main symptoms was that when my nose or fingers got cold they began to hurt - a lot. Curiously it went away again later, then came back later still. I later learned that too much vitamin b6 can cause peripheral neuropathy...

Quote from an mecfs person who had the neck-fusion surgery, taken from the open internet: "do not mess with your neck. I made that mistake and will pay for it forever - in spades." I'm actually open-minded about whether it might be causal in some cases and I"m way more forgiving of people...

Apparently a taste for sour foods is more common among kids? Idk if anyone believes this guy can link observation and theory tho:

I really enjoy a sour orange but not so much a sweet orange. I've always had a fondness for lemon-flavoured cakes and tarts and gelati. I like green apples too, but I can't isolate a deitary fondness for malic acid !