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This is an apt comment; I think it points to how trends in understanding medicine determine what gets cured in each era. Another of my favourite examples is scurvy, which was famously "cured" centuries ago, but then scurvy came roaring back among polar explorers only 100 years ago and the Royal...

I'm in Australia and I got malic acid in powder form from a home brew company selling it on eBay. very cheap compared to tablets albeit with a delivery fee. I got 200g for $18 or so. This might sound weird but I absolutely love it. I add a pinch, maybe a quarter of a gram ,to 500mL of water...

The short answer is epidemiology. In the early 1940s in the Netherlands they had no wheat. The children's doctor who was usually in charge of coeliac cases found himself putting his feet up for a few years. While twiddling his thumbs, he developed a hypothesis, and later tested it. In my...

Yes! I look forward to being able to say, aha, this is why the rituximab study showed this, or why this scientists went down this rabbit hole, or why these people from this culture /with these genetics didn't seem to suffer so badly, etc etc. I'm also wondering if by imagining ourselves in that...

I've done six things at the same time to help get rid of my histamine intolerance and they seem to have worked. I will now test them one at a time to see what was the biggest and most important part. 1. Cut out shark liver oil which I was taking; fish are famously a source of histmaines and the...

Agree with that in general. What do you think about the inverse idea - that being in rolling PEM can lower your baseline ?

Here's another familiar-seeming snippet on the history of coeliac: before they know the cause, some doctors propose it has a "nervous" cause.

Among the implications of the banana diet is a rebuttal to the popular saying: "if that worked we'd know." This diet did work, at least as long as the coeliacs stuck to it, but it was not considered legitimate. I suspect we view evidence through a theory lens and tend to dimsiss evidence that...

One made-up example about pacing: Say our blood vessels are providing inappropriate blood flow to the brain and scientists discover that the brain is exceptionally sensitive when blood flow error signals are on both the high and low side, and calls in a centrally-mediated immune reaction...

Before coeliac disease was understood, there was the banana diet. It was something of a joke at the time, but coeliac disease was fatal for children and so people were desperate. We now know that it would work as a coeliac treatment and why. Today it seems far less crazy. But at the time the...

This matches my experience too. Even though my strength is okay (can lift my 20kg child easily), and my fitness is okay (could do a ten minute bike ride right now). I can't do a full day of activity, or even a half day, or even an hour on my feet really, without big PEM. I need to intersperse...

I agree with this, we will not be afforded the luxury of being immune to deconditioning. It's not the number one cause of our problems, not by a long shot. And even if it is there, doesn't mean doing exercise is worth it. The short-run symptom cost of exercising is for most people greater than...

If you're in R this wll print an r^2 value right on top of your chart install.packages(ggpmisc) library(ggpmisc) p+stat_poly_eq() https://www.rdocumentation.org/packages/ggpmisc/versions/0.6.0/topics/stat_poly_eq

A good spreadhseet for the human eye would have studies in rows and molecules in columns. But I think this data would be too big for the eye. You'd need what they call long data, or tidy data, where each row contains only one patient-to-control ratio, and many markers by which you can filter...

Peroxidasin is intersting to me, it might help explain POTS Mammalian Peroxidasin (PXDN): From Physiology to Pathology PXDN expresses in the endothelial cells and secretes into blood. PXDN exhibits with much higher concentration in plasma than MPO [20]. Therefore, it is reasonable to speculate...

Should you filter for low p values before running your correlation? if the studies truly correspond you'd find lots of things measured at 1:1 in both studies, there will be a cloud around the centre of the plot and it won't affect your r^2. I think running the correlation on the full dataset is...

There's a reference to photo-staining t-cells from fat and then finding them in the brain. I think. Is this paper saying t-cells are travelling from the fat to the brain?

This is a good warning. I've taken to buying some of my more expensive supplements from Aliexpress, which is even riskier! (Ubiquinol is sooo expensive!) I should probably stop doing that.

I've just read the paper and I'd like to praise the writing in it. Clear and accessible, chatty but somehow still formal, it's a rare treat to encounter something so well put together.

This is a really good point - AI keeps changing. I see people saying things about it that were true a few months ago, e.g. "it can't even draw fingers!" that are simply not true any more. If you take a principled stand against AI and stop using it (which is probably a good idea!), you don't...