Search results for query: NEGR1

It’s interesting to me that NEGR1, is highly expressed in the hypothalamus and specifically in the PVN. Also that this is where this CRH neurons live inside, the PVN. I might be trying to hard to connect these two.

Cross posting from olfactory thread, as these are related to NEGR1: Post in thread 'Human Olfactory Receptors: Novel Cellular Functions Outside of the Nose, 2018, Maßberg et al'...

I saw this weird Negr1 olfactory paper yesterday when combing through NEGR1 papers: https://pubmed.ncbi.nlm.nih.gov/39170714/ https://www.researchgate.net/figure/Deletion-of-Negr1-resulted-in-impaired-sensory-function-in-mice-A-olfactory-function_fig4_384456792

Is it possible to link poor functioning NEGR1 gene to the loss of the CHR neurons? Edit: I asked Gemini, and it’s so far outside my knowledge I don’t know if I just got slop back: “ Summary of the Hypothesis While there is likely no direct paper linking NEGR1 to this specific ME/CFS autopsy...

Was just pulling up papers with this and saw this: Elevated NEGR1 in brain induces anxiety or depression-like phenotypes and synaptic dysfunction - PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC12436153/#:~:text=Neuronal sparse labeling assay and,loss and synaptic ultrastructure abnormality...

NEGR1 deficiency disrupts lipid metabolism and steroidogenesis in Leydig cells, linking testosterone to behavior (2025) Web | PDF | Journal of Lipid Research | Open Access

...in DecodeME. I guess we'll need a larger GWAS or multi-ancestry to see them separated out more clearly. @ME/CFS Science Blog also previously looked at where the depression NEGR1 lead SNP sits, relative to DecodeME. It looks like the anxiety and depression loci are pretty much in the same...

That looks different enough for me. I guess there might be two effects operating with one common to the two analyses but one to the right but I still don't really have a feel for what these pictures of kite-competitions-over-Mumbai-plots mean in detail.

Not quite. The top NEGR1 variant from this paper is highlighted, overlaid on DecodeME's results:

Looking at the gene cards for the non coding elements a number of these seem to be promoters/enhancers related to NEGR1. I guess not surprising given the proximity. But could here be something here (and potentially with other variants or near misses on significance) which means we’re seeing...

The LDSC genetic correlation with depression was 0.9, which seems very high. Apart from NEGR1 and the BTN hits, most seem quite different from those found in DecodeME. Here's the Manhattan plot:

LocusZoom for this location on DecodeME data with some things going on just along to the right if you scroll along or zoom out… And the Genecard

A quick look on AI. The NEGR1 (Neuronal Growth Regulator 1) gene, located on chromosome 1p31.1, encodes a GPI-anchored cell adhesion molecule critical for brain development, synaptic organization, and neuronal connectivity. Strongly associated with obesity, depression, and neurodevelopmental...

Are the NEGR1 hits coinciding, can we tell? What I like about the BTN one is that it seems to indicate that this is not just some fluff picked up as an artefact of cohort selection for GWAS studies or diagnostic overspill because it is a different locus. NEGR1 looks like the sort of gene that...

NEGR1 was noted in Temporal dynamics of the plasma proteomic landscape reveals maladaptation in ME/CFS following exertion (2025) —

NEGR1 was almost significant in DecodeME, and has had significant associations in depression GWASs. It's mentioned here for anxiety:

Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling The major anxiety disorders (ANX; including generalized anxiety disorder, panic disorder and phobias) are highly prevalent, often onset early and...

NEGR1 is also familiar.

...function (HLA-DQB1, BCL11A), extracellular matrix remodeling (COL11A1, ADAMTS17, LOXL4), axon guidance and neural development (DCC, ETV1, NEGR1), and carpal tunnel syndrome (DIRC3). Public variant association data across cohorts, genetic correlation, and Mendelian randomization analyses...

So I think the association is: measure the peak VO2 after a single exercise test, and measure NEGR1 in the plasma immediately after the exercise. In people with ME/CFS, the higher the VO2, the higher the NEGR1. And in controls, the correlation was not significant. I'm hesitant to put too much...