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Ditto integrity.

...evidence that the distribution of numbers of participants withdrawing from the trials was implausible, frequently contradictory reporting of the size of participant populations, implausibly prolific research activity, unethical conduct, and very frequent discrepancies between trial...

If there was a disease process underlying ME/CFS it would have already been found. No matter the cause, organ damage/disease is quite easily identified with current tools – clinical exam, routine bloodwork, and diagnostic imaging. And yet important discoveries continue. Not ME/CFS related (far...

To develop the CAN-PCC guidelines, McMaster University’s GRADE Centre collaborated with Cochrane Canada, an arm of the Cochrane Collaboration. I think I am on the verge of spotting the problem here.

Good interview, and good for Dutch patients to have somebody like Zurhake on the case. :thumbup:

The similarities between Long COVID and ME/CFS have given researchers new urgency to find real solutions. Many of us in functional medicine... I stopped reading there. Anytime I see the word 'functional' in this context I see a major red flag with Snake Oil Merchant written all over it.

I am not expecting any serious issues for the vast majority of patients, who I think will simply start getting on with what is left of their lives. The biggest problem is going to be stuff like recovering financially, and dealing the often decades long extreme trauma and personal loss many of...

ME/CFS shares many of the same characteristics as other functional disorders (acute/subacute onset often after a physical or mental stressor, fluctuating symptoms often moment to moment or day to day, and disability level out of proportion to exam findings/pathology). Also, it is highly comorbid...

I use an $8 plastic dustpan brush. Get maybe 12 months out it. One of these:

Recovery depends on positive patient engagement with the process. If our pseudo-treatment doesn't work it is the patient's fault. Yep. It is the mother of all double-binds.

marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing marketing...

I am at the point where merely getting the psycho-tyrants off my back for what remains of my life existence would be a major win, let alone getting a good treatment, or even a cure. Though, of course, I would love a good treatment or a cure as much as anybody, and want competent research into...

This.

such as symptoms that cannot be explained medically.... physical symptoms where healthcare cannot demonstrate objective findings for physical illness. Can never demonstrate, or has not yet been demonstrated? Because it is a very critical distinction, which he did not make clear. In the first...

Phil Hammond is no friend to us.

What is the definition of structural in medicine? Is it confined to a specific tissue or group of morphologically coherent tissues (e.g. red blood cells, bone, muscle, an organ)? In particular, does structural pathology have to be either more-or-less static (e.g. a missing limb), or which only...

Yes, it is going to be interesting to see how far back the technology and knowledge existed to have enabled the basics to be revealed. If it turns out it enough of the basics could have been known decades back there will be hell to pay. :mad:

We postulate... we speculate... Yeah, we know.

Unfalisifiable, then. Alleged positive signs not withstanding.

Nor anything else. The Oxford criteria as basically just prolonged fatigue with no other (known) explanation.