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I think it could work with an increased number of lactotrophs or greater responsiveness of those lactotrophs for some reason. With largely steady state levels the balance between supressjon from dopamine and everything else would be just fine. It would only be with sharp changes in levels that...

That’s it for the big posts. But hopefully a good overview of what these cells are! Those two papers were substantial reviews of many papers themselves so reducing their content wasn’t easy. It was at least useful for me in learning about them so I hope it may be for others. Overall it seems...

That’s it for the big posts. But hopefully a good overview of what these cells are! Those two papers were substantial reviews of many papers themselves so reducing their content wasn’t easy. It was at least useful for me in learning about them so I hope it may be for others.

A coordinator or the various pituitary axes and pulse generation Plasticity, remodelling over time and memory Changes over time

Some more details, there’s a lot in this review! I may need to come back and split it up a bit (sorry for the wall of text but if I don’t post it I’ll lose the text or my mind) but some highlights Edit: Still a lot of text but hopefully easier now it’s in sections. Structure and extra cellular...

I do like the sound of that. If it was confirmed there’s something going on around lactotrophs maybe we can get endocrinologists interested. And they can look at FS cells :D There may be nothing. But there may be something! FS cells could potentially tie in with changes in numbers of or...

As far as I can tell they’re just picking up the press release from a month ago from the university which @Hutan posted here. Nothing new here, no new information. Since they’re repeating themselves so will I They’ve claimed they have a blood test for me/cfs and now this. We’d all love there...

Next paper, the one @V.R.T. mentioned and I’ll start with those bits from the abstract as they’re intriguing, but then dive into the rest of the paper Renewing an old interest: Pituitary folliculostellate cells, 2021, Le Tissier et al Le Tissier, Paul R.; Mollard, Patrice Web | DOI | PMC | PDF...

Difficult to know where to start. But looking at their Research pages may be a good start https://www.actionforme.org.uk/research-campaigns/our-research-work/sequenceme-long-covid/ Or any of their recent webinars on or around DecodeME or PRIME or discussion of them on here, there’s a few threads...

The problem is not that patients find psychotherapeutic practices stressful. It’s that they do not work for ME/CFS and are not appropriate for ME/CFS. They have been tried. They have not worked in the way proposed here. This theory and branch of thought is an ex parrot. It is not resting or...

Thanks Chris, I’m sure we’d all help spread the news of that if we can! Are you able to tell us if using the techniques from this paper would enable you to look at subgroups by severity within the DecodeME cohort?

My summary would be that the FS cells act as scaffolding and a mesh around the hormone producing cells, they were thought to do nothing more and not easy to study until it was found they express the marker protein S100B. Interestingly this is a glial protein primarily expressed by astrocytes, so...

Rather than posting full papers and abstracts I’ll include their details and some selected passages that I find interesting and maybe some of my notes. So a bit curated and interpreted, but hopefully not too far off the mark! The more modern review @V.R.T. linked to is a good place to start...

How does modulating the recovery dynamics of biological systems through psychotherapy go for other biological diseases? I wish people would stop with this stuff. It doesn’t help people with ME/CFS and it doesn’t help the reputation of psychotherapy. Rather it harms both.

That’s a really good question! I’d be interested in hearing what others think. Given discussion in the prolactin thread I wonder if there’s any PET tracers which could be used to measure relevant signalling molecules or just measuring blood levels (they may be masked and not give us cell...

I have loads more half made notes and papers to go through. I don’t want to paste things which may mislead. Bear with me and hopefully I’ll be able to get to more in time. And hopefully others will be able to help answer the questions which arise. I’d never heard of these things until this week...

If things pop they’ll be a hit and a panic in some markets but this isn’t as significant in the real economy I don’t think. Stocks may crash but the debt is localised. GDP has been made to look good in some places by capital expenditure. But there is no need for government or central banks to...

Wikipedia is a good place to start as is often the case Folliculostellate cell And there’s an abstract here: Folliculostellate cells: what are they?

Starting a separate thread on these cells which I mentioned in the buspirone/prolactin thread here. This may just be something I’m interested in for new shiny novelty reasons but I haven’t found any discussion on the forum and they seem really interesting and also potentially relevant to various...

More signs that the economics don’t add up. Google are further restricting personal/free access https://support.google.com/gemini/answer/17004136 AI everywhere all at once seems to be ending. The steady march towards ‘how the hell do we make any money here’ is accelerating.