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And this paper talks about effects of inhibiting CD38, which I think an anti-cd38 mab would do in some circumstances? May tie in to the NAD+ stuff above? Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide‐induced microglial and astrocytic...

I have been pondering astrocytes and CD38 and apparently daratumumab (edit: may be able to) cross the blood brain barrier The Daratumumab Crosses the Blood Brain Barrier, 2018, Vercruyssen et al Vercruyssen, Marie; El Hachem, Georges; Maerevoet, Marie Abstract NK/T cell lymphoma is a rare...

Speaking about some symptoms with my mum who has PD there are sometimes similarities. Obviously around sleep problems but also just other sort of neurological oddities, sometimes what people make cause physical/emotional responses and hypersensitivity but in PD they’re more clearly tied into the...

Some ideas to help people if they choose to write to their MP, an organ8ed campaign may help but we don’t need to wait and it all helps https://www.s4me.info/threads/asking-uk-mps-to-get-behind-funding-sequenceme-and-wider-investment.45551/

Sorry if this goes off on a tangent, I’ve not kept up with the discussion but had more thoughts on those topic, s9me notes from this week. Particularly while thinking about a lot of the unpleasant symptoms I’ve been experiencing this week and how they could be explained. So we’re looking for a...

What is is you find interesting here? Can you elaborate.

I wonder if there can be things learnt from findings like the drop off in grip strength on repeated grips here? What sort of neural cells and mechanisms could be involved there? That seems like perhaps a more known or understood area than some others?

@Timko I don’t know about others but I don’t think it needs to be one or the other. I see a few interconnected systems at play. You could have something like the issues with interferon-response resolution @jnmaciuch talks about but also something a little off with say certain NK cells or their...

In the same way as we have certain immune cells primed or more easily activated we can have certain neural cells, specific groups of neurons, primed and therefore closer to (or further from) their threshold potential. So making them easier or harder to trigger. The idea of either a shift in...

Nothing useful to add atm other than to say something like fluctuating crosstalk within specific neural cell groups subjectively feels like a lot better explanation for a lot of my experiences than other theories. Not to say this is the whole explanation of course. More a few different loops in...

You’re vey welcome, glad to hear it’s useful. I’m very interested to hear what you and others make of it all.

Some more background info: Source: https://neuroscientificallychallenged.com/posts/know-your-brain-striatum

This is a review but links to the various papers which have evidence for the concepts discussed. Some areas seem speculative. Others more clear. But there’s some interesting ideas discussed which seem to useful to various discussions including those in this thread on butyrophilin-like genes...

Thanks again, good to hear all this. I need to read all the discussion here properly but have been wondering about the reported changes in NK function or talk of ‘exhausted’ NK cells and if this was more a case of them just being different. And on possibly relevowith Fluge and Mella’s work...

Power of Memory: A Natural Killer Cell Perspective Sinha, Oishi; Abhipsha, SK; Sen Santara, Sumit Abstract Memory is an incredible aspect of our immune system. Similarly to our cognitive memory, it allows us to remember and respond more efficiently to subsequent encounters with the same...

Thanks Jonathan this is all really useful. Over recent months I’ve been reading some papers about memory or memory like NK cells, which after exposure to cytokines can hang around for a long time with lower thresholds for activation. I’m not sure if this ties in with the behaviour you mention...

Catching up partially here, but would BTN2A1 tie in more with the idea of a sort of innate autoimmune condition rather than adaptive? Are autoimmune conditions normally seen as adaptive? Is there such a thing as innate autoimmunity? I’m thinking along the line of longer lived memory NK cells.

Thanks!

Thinking some more about brain regions to look at, rather than focusing on where CA10 is relatively highly expressed, maybe looking at where other genes are too may be worthwhile? For that, best look at the whole heatmap for DecodeME and squint a bit...

There’s apparently a known sex bias in the occurrence of allergies too, something which popped up listening to this https://www.bbc.co.uk/sounds/play/m001byym When younger, males show more allergies, but during puberty this changes and females catch up then overtake, with women more likely to...