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Agree, confirmed in this trial registration and supplementary material of the protocol. https://clinicaltrials.gov/study/NCT05212467 But it's strange that this study on Long Covid is doing a large trial that includes other patients as well (fibromyalgia prevalence is like 2-4%). The EU grant...

Looks like the authors shared preliminary results in this document to the EU (see attachment). There were no significant group differences for the three main outcomes. This is from a preliminary analysis that includes only 215 out of necessary 270 patients but the report writes that "there is...

Looks like this is funded by the EU grant on Long Covid: Here's the link to the EU page on the project which received 6.5 million in funding. Decision support for prediction and management of Long Covid Syndrome (LCS) | Long Covid | Project | Fact Sheet | HORIZON | CORDIS | European Commission...

Thanks @forestglip Used AI to screen these genes on function and these two might be interesting: ITGAE - facilitates adhesion of T-lymphocytes to epithelial cell TECPR2 - aids in the formation of autophagosomes

Made this summary of the paper: 1) Trigger warning: suicide This paper analyzed 505 entries on the National CFIDS Foundation memorial list. These were people with ME/CFS who passed away. The messages summarize their life, illness and struggles. The researchers grouped these into several...

Thanks for doing this. One issue I see is that we don't have a standardized measure of effect size to filter these. I suspect that in a lot of the things that come up like smoking, overall health and cognitive tests, the DNA has only very minor effects and that they only come up because these...

It seems that in this study the authors pre-selected only 22 traits because they have previously been implicated in ME/CFS and the brain/synapses was not included. The full list is in table 1 in the online methods. Most did not reach high correlations. Migraine and IBS were already known to be...

Anyone has any updates on this? No update or changes on the journal website yet from what I can see https://onlinelibrary.wiley.com/doi/10.1002/hbm.70505

Another paper on this for those interested: Link: https://pubmed.ncbi.nlm.nih.gov/11705431/

An addditional study by these authors, this time using GP records in 11 practices in Devon, UK. They found that CFS patients had more GP consultations for various complaints in the 15 years before their diagnosis than controls with MS. This could point that CFS patients were never truly...

Excellent blog, clearly written, thanks! Perhaps not very relevant but Jason also looked at seasonal onset in his Chicago cohort and found significantly more cases where onset was in January compared to other months. Seems likely to be due to chance in my opinion (it had a low sample size of...

Found this old 2001 paper on Chiari malformation surgery in fibromyalgia and CFS Can fibromyalgia and chronic fatigue syndrome be cured by surgery?

Older 2-day CPET studies such as the one by Davenport also used the Fukuda criteria so that alone likely wouldn't explain the results. Severe ME/CFS patients can't do these test so highly likely that these were mild-moderate patients just like in previous 2-day CPET studies. The idea was that...

Hard to take anything useful from this paper... Seems like all of Jason's studies are now based on that distinction between moderate ME/CFS and severe ME/CFS. But the latter is not actually severe ME/CFS, just patients that meet more than one case definition for ME/CFS. They then conclude...

Think it's mentioned in the text, not in a table.

Been a while since I read this paper but think this is found in the test by group interaction of their ANOVA modelling.

Looks like they failed to replicate the 2-day CPET results, although look forward to seeing the actual data. The most replicated finding was workload at the ventilatory threshold which they don't report in this abstract.

An older study that I hadn't seen discussed much. It uses insurance data of the company Medical Sickness Group. Found 133 CFS cases and compared them to MS patients and non-claimant controls. They could look at a median of 10 years before the claim of CFS. Results showed that ME/CFS patients in...

Link: https://pubmed.ncbi.nlm.nih.gov/9507441/

Don't remember, this was back in 2021. Probably no reason, just a rejection.