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Human Brain Cell Atlas v1.0 This is currently the most extensive dataset on brain cells in humans. Published in 2023 by the lab of Sten Linnarsson at the Karolinska Institute, one of the important teams that have been making multiple RNA datasets over the years. The relevant paper is Siletti...

GTEx6 + Franke Lab An older version of the GTEx (version 6) was combined with RNA data from Franke's lab in the study by Hilary Finucane et al. 2018. This is the paper where they introduced the LDSC-SEG approach to testing cell type enrichment and where they tested multiple diseases and traits...

Genotype-Tissue Expression (GTEx) This analysis was done in the DecodeME preprint using the MAGMA tool on the FUMA website. The preprint only posted some of the most significant regions, but the entire plot looks something like this if you upload the DecodeME data. All significant tissue types...

I thought it would be useful to make an overview of RNA datasets that we can match to the DecodeME DNA results. This could give us clues to which tissues or cell types are potentially involved in ME/CFS. I've made an overview of datasets below and plan to update it as we find new ones. The Chan...

This is a recent preprint from the researchers who maintain the FUMA website on the cell type analysis they do, matching GWAS data to RNA databases. They created 388 datasets from 36 studies and tested these in 14 brain traits and diseases. Here's one of their graphs. I noticed that...

Abstract Genome-wide association studies (GWAS) have yielded unprecedented insight into the genetic variants associated with many human traits. However, translating this insight into knowledge about causal biological mechanisms remains challenging. One promising recent strategy is to link...

Thanks, updated. Here it is again: https://www.nature.com/articles/s41588-018-0081-4

Many of the GWAS in this analyses were underpowered so no significant result could simply mean too small sample size. Migraine without aura did have a significant result for the cardiovascular system. EDIT: accidentaly wrote migraine with aura, but it is without aura that I meant.

Yes these are in the supplementary material of the paper, table 6.

One interpretation could be that what sticks out in the (still underpowered) DecodeME results is what every ME/CFS patient has in common. So this may point to the neural networks that produce sickness behavior symptoms such as fatigue. Hence the strong overlap with fibromyalgia. Behind there...

I also did the gene expression data from the Immunological Genome (ImmGen) project that Finucane et al. prepared for their pipeline. Immunological Genome Project Similar results to trafalmadorian97, with the top hit reaching a p-value around 0.005 for 292 cell types tested, not even close to...

I've added the DecodeME into the same pipeline. LDSC-SEG is quite complex to set up (their baseline model has 52 annotations), but I got results that are very similar to what @tralfamadorian97 found...

This was one of the early papers that matched GWAS data with scRNA-seq data from cell types. They used the LDSC method which is based on a regression between the chi-square statistic from GWAS (the association with a SNP and the disease) and LD (Linkage disequilibrium score, how much an SNP is...

Abstract We introduce an approach to identify disease-relevant tissues and cell types by analyzing gene expression data together with genome-wide association study (GWAS) summary statistics. Our approach uses stratified linkage disequilibrium (LD) score regression to test whether disease...

Do we also have a thread where members can indicate their willingness to participate in a research project as a patient representative? The willing and available thread is much broader and also asks about roles in charities, the media, and the forum itself. So perhaps we could create a...

I suppose this is the thread where researchers looking for PPI can make a request on S4ME: https://s4me.info/threads/patient-and-public-involvement-opportunities-in-me-cfs-and-other-research.35017/ The call says that "meaningful involvement of patients and/or patient representatives is...

Can anyone explain how people registering their interest would have changed anything? As Jo already argued the committee probably assumed everyone was interested before making a choice. So is it mainly about resumes and official qualifications not being considered?

The paper also focuses on the subgroup comparison of LC patients with or without PEM. Would be more interesting to focus on the LC versus database control comparison. I suspect that Table 2 shows z-values, which indicate how many standard deviations the mean is from the control data. If you...

Big limitation that the controls were from a database: Well spotted; this makes it more likely that they simply didn't do Bonferroni correction at all.

Great that WE&ME is doing this! It says the call is funded entirely by them, and with 7 x €150,000, that would be around one million euros that they put in. It feels like recognition of S4ME, that they are involving multiple members in the jury that decides how this money will be spent. I think...